ArticleBiological psychology2012
A heartfelt response: Oxytocin effects on response to social stress in men and women.
Article in Biological psychology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01011465 (The Biology of Resilience), which is not on this map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Biology of Resilience: Oxytocin, Social Relationships and Health
Who cites it
58 citing papers in PubMed, 146 citations in OpenAlex.
- Temporal profile of intranasal oxytocin in the human autonomic nervous system at rest: An electrocardiography and pupillometry study.Journal of psychopharmacology (Oxford, England) · 2023Trial
- The role of oxytocin in delay of gratification and flexibility in non-social decision making.eLife · 2021Trial
- Oxytocin-enhanced group therapy for methamphetamine use disorder: Randomized controlled trial.Journal of substance abuse treatment · 2020Trial
- Effects of oxytocin and vasopressin on the neural response to unreciprocated cooperation within brain regions involved in stress and anxiety in men and women.Brain imaging and behavior · 2016Trial
- Estradiol variability, stressful life events, and the emergence of depressive symptomatology during the menopausal transition.Menopause (New York, N.Y.) · 2016Trial
- Oxytocin and vasopressin modulate risk-taking.Physiology & behavior · 2015Trial
- Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial.BMC psychiatry · 2014Trial
- The influence of group physical activity on oxytocin, empathy, affect, and stress in individuals with schizophrenia spectrum disorders in a single-arm, pilot and exploratory study.Discover mental health · 2026Article
- Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Altered association of plasmatic oxytocin with affective stress response in alcohol use disorder.Translational psychiatry · 2025Article
- Social isolation induces sexually aggressive behaviour in male Wistar rats.BMC neuroscience · 2025Article
- Effects of intranasal oxytocin on cigarette withdrawal and smoking in the laboratory: Differences by sex and social functioning traits.Experimental and clinical psychopharmacology · 2024Article
- Cardiovascular reactivity during conversations about discrimination is buffered by social support among U.S. Latines.Scientific reports · 2024Article
- Understanding the Development of Chronic Loneliness in Youth.Child development perspectives · 2024Article
- Sex differences in the effects of individual anxiety state on regional responses to negative emotional scenes.Biology of sex differences · 2024Article
- Bridging childhood to adulthood: the impact of early life stress on acute stress responses.Frontiers in psychiatry · 2024Article
- Oxytocin receptors in the Magel2 mouse model of autism: Specific region, age, sex and oxytocin treatment effects.Frontiers in neuroscience · 2023Article
- The effect of oxytocin and an enriched environment on anxiety-like behaviour and corticosterone levels in a prenatally stressed febrile seizure rat model.IBRO neuroscience reports · 2022Article
- Shared Reality Can Reduce Stressor Reactivity.Frontiers in psychology · 2022Article
- The effects of intranasal oxytocin on black participants' responses to outgroup acceptance and rejection.Frontiers in psychology · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAnimal research indicates that oxytocin is involved in social behavior, stress regulation, and positive physiologic adaptation. This study examines whether oxytocin enhances adaptive responses to social stress and compares effects between men and women.
methodsHypotheses were tested with a placebo-controlled, double-blind experiment. Social stress was induced. Changes in cardiovascular reactivity, affect, and behavior were assessed.
resultsParticipants given oxytocin, relative to placebo, responded to social stress with a challenge orientation characterized by a benign pattern of cardiovascular reactivity. Gender differences emerged. Men given oxytocin reported less negative affect and had greater vagal rebound, while women given oxytocin reported more anger and had better math performance following social stress. DISCUSSION: Findings indicate oxytocin stimulates an approach-oriented cardiovascular profile during social stress, suggesting mechanisms by which oxytocin might improve physical health. However, before considering oxytocin as therapeutic or uniformly enhancing health, greater understanding of possible gender differences in effects is needed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.