ArticleMutation research2012
The use of next generation sequencing technology to study the effect of radiation therapy on mitochondrial DNA mutation.
Article in Mutation research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- The quality and detection limits of mitochondrial heteroplasmy by long read nanopore sequencing.Scientific reports · 2024Article
- Genetic Diversity, Heteroplasmy, and Recombination in Mitochondrial Genomes of Daphnia pulex, Daphnia pulicaria, and Daphnia obtusa.Molecular biology and evolution · 2022Article
- Ideafix: a decision tree-based method for the refinement of variants in FFPE DNA sequencing data.NAR genomics and bioinformatics · 2021Article
- The Likelihood of Adverse Pregnancy Outcomes and Genetic Disease (Transgenerational Effects) from Exposure to Radioactive Fallout from the 1945 Trinity Atomic Bomb Test.Health physics · 2020Article
- Recent Advances in Detecting Mitochondrial DNA Heteroplasmic Variations.Molecules (Basel, Switzerland) · 2018Review
- The first in vivo multiparametric comparison of different radiation exposure biomarkers in human blood.PloS one · 2018Article
- Mitochondrial mutations drive prostate cancer aggression.Nature communications · 2017Article
- A comprehensive analysis of mitochondrial genes variants and their association with antipsychotic-induced weight gain.Schizophrenia research · 2017Article
- mtDNA-Server: next-generation sequencing data analysis of human mitochondrial DNA in the cloud.Nucleic acids research · 2016Article
- Obstetric and offspring risks of women's morbid conditions linked to prior anticancer treatments.Reproductive biology and endocrinology : RB&E · 2016Review
- Mitochondria sequence mapping strategies and practicability of mitochondria variant detection from exome and RNA sequencing data.Briefings in bioinformatics · 2016Article
- Genome measures used for quality control are dependent on gene function and ancestry.Bioinformatics (Oxford, England) · 2015Article
- Article
- Aging: A mitochondrial DNA perspective, critical analysis and an update.World journal of experimental medicine · 2014Review
- Three-stage quality control strategies for DNA re-sequencing data.Briefings in bioinformatics · 2014Review
- High-throughput sequencing in mitochondrial DNA research.Mitochondrion · 2014Review
- Very low-level heteroplasmy mtDNA variations are inherited in humans.Journal of genetics and genomics = Yi chuan xue bao · 2013Article
- Finding the lost treasures in exome sequencing data.Trends in genetics : TIG · 2013Review
- MitoSeek: extracting mitochondria information and performing high-throughput mitochondria sequencing analysis.Bioinformatics (Oxford, England) · 2013Article
- The effect of strand bias in Illumina short-read sequencing data.BMC genomics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 9 institutions in 4 countries.
Funding
Abstract
The human mitochondrial genome has an exclusively maternal mode of inheritance. Mitochondrial DNA (mtDNA) is particularly vulnerable to environmental insults due in part to an underdeveloped DNA repair system, limited to base excision and homologous recombination repair. Radiation exposure to the ovaries may cause mtDNA mutations in oocytes, which may in turn be transmitted to offspring. We hypothesized that the children of female cancer survivors who received radiation therapy may have an increased rate of mtDNA heteroplasmy mutations, which conceivably could increase their risk of developing cancer and other diseases. We evaluated 44 DNA blood samples from 17 Danish and 1 Finnish families (18 mothers and 26 children). All mothers had been treated for cancer as children and radiation doses to their ovaries were determined based on medical records and computational models. DNA samples were sequenced for the entire mitochondrial genome using the Illumina GAII system. Mother's age at sample collection was positively correlated with mtDNA heteroplasmy mutations. There was evidence of heteroplasmy inheritance in that 9 of the 18 families had at least one child who inherited at least one heteroplasmy site from his or her mother. No significant difference in single nucleotide polymorphisms between mother and offspring, however, was observed. Radiation therapy dose to ovaries also was not significantly associated with the heteroplasmy mutation rate among mothers and children. No evidence was found that radiotherapy for pediatric cancer is associated with the mitochondrial genome mutation rate in female cancer survivors and their children.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.