ArticleMolecular and biochemical parasitology2012
Effect of human TGF-β on the gene expression profile of Schistosoma mansoni adult worms.
Article in Molecular and biochemical parasitology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Schistosome TRP channels: An appraisal.International journal for parasitology. Drugs and drug resistance · 2020Review
- Schistosoma japonicum extracellular vesicle miRNA cargo regulates host macrophage functions facilitating parasitism.PLoS pathogens · 2019Article
- The role of fibroblast growth factor signalling in Echinococcus multilocularis development and host-parasite interaction.PLoS neglected tropical diseases · 2019Article
- Effect of Transforming Growth Factor-β upon Taenia solium and Taenia crassiceps Cysticerci.Scientific reports · 2017Article
- Quantitative multiplexed proteomics of Taenia solium cysts obtained from the skeletal muscle and central nervous system of pigs.PLoS neglected tropical diseases · 2017Article
- Article
- Molecular Cloning and Characterization of a P38-Like Mitogen-Activated Protein Kinase fromThe Korean journal of parasitology · 2016Article
- Molecular characterization of host-parasite cell signalling in Schistosoma mansoni during early development.Scientific reports · 2016Article
- MicroRNAs Are Involved in the Regulation of Ovary Development in the Pathogenic Blood Fluke Schistosoma japonicum.PLoS pathogens · 2016Article
- Imatinib treatment causes substantial transcriptional changes in adult Schistosoma mansoni in vitro exhibiting pleiotropic effects.PLoS neglected tropical diseases · 2014Article
- Transcriptome analyses of inhibitor-treated schistosome females provide evidence for cooperating Src-kinase and TGFβ receptor pathways controlling mitosis and eggshell formation.PLoS pathogens · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Schistosoma mansoni is responsible for schistosomiasis, a parasitic disease that affects 200 million people worldwide. Molecular mechanisms of host-parasite interaction are complex and involve a crosstalk between host signals and parasite receptors. TGF-β signaling pathway has been shown to play an important role in S. mansoni development and embryogenesis. In particular human (h) TGF-β has been shown to bind to a S. mansoni receptor, transduce a signal that regulates the expression of a schistosome target gene. Here we describe 381 parasite genes whose expression levels are affected by in vitro treatment with hTGF-β. Among these differentially expressed genes we highlight genes related to morphology, development and cell cycle that could be players of cytokine effects on the parasite. We confirm by qPCR the expression changes detected with microarrays for 5 out of 7 selected genes. We also highlight a set of non-coding RNAs transcribed from the same loci of protein-coding genes that are differentially expressed upon hTGF-β treatment. These datasets offer potential targets to be explored in order to understand the molecular mechanisms behind the possible role of hTGF-β effects on parasite biology.
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