ArticleJournal of immunology (Baltimore, Md. : 1950)2012
Neutrophilic granulocytes modulate invariant NKT cell function in mice and humans.
Article in Journal of immunology (Baltimore, Md. : 1950), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Trial
- Interaction between gut microbiota and immunity in health and intestinal disease.Frontiers in immunology · 2025Review
- Gut Microbiota and Immune System Dynamics in Parkinson's and Alzheimer's Diseases.International journal of molecular sciences · 2024Review
- Gut microbiota and acute kidney injury: immunological crosstalk link.International urology and nephrology · 2024Review
- invariant Natural Killer T cell therapy as a novel therapeutic approach in hematological malignancies.Frontiers in transplantation · 2024Review
- Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease.Nature reviews. Immunology · 2023Review
- Neutrophil sub-types in maintaining immune homeostasis during steady state, infections and sterile inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Review
- Host innate and adaptive immunity shapes the gut microbiota biogeography.Microbiology and immunology · 2022Article
- The crosstalk between the gut microbiota and tumor immunity: Implications for cancer progression and treatment outcomes.Frontiers in immunology · 2022Review
- Miltefosine enhances infectivity of a miltefosine-resistant Leishmania infantum strain by attenuating its innate immune recognition.PLoS neglected tropical diseases · 2021Article
- The Role of NKT Cells in Glioblastoma.Cells · 2021Review
- Alcohol-associated intestinal dysbiosis alters mucosal-associated invariant T-cell phenotype and function.Alcoholism, clinical and experimental research · 2021Article
- Interaction between microbiota and immunity in health and disease.Cell research · 2020Review
- CD1-Restricted T Cells During Persistent Virus Infections: "Sympathy for the Devil".Frontiers in immunology · 2018Review
- The Pathophysiological Relevance of the iNKT Cell/Mononuclear Phagocyte Crosstalk in Tissues.Frontiers in immunology · 2018Review
- Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses.Nature immunology · 2016Article
- Selective Conditions Are Required for the Induction of Invariant NKT Cell Hyporesponsiveness by Antigenic Stimulation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Invariant natural killer T cells are depleted in renal impairment and recover after kidney transplantation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2014Article
- The B cell helper side of neutrophils.Journal of leukocyte biology · 2013Review
- Neutrophils in innate and adaptive immunity.Seminars in immunopathology · 2013Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Invariant NKT (iNKT) cells are a conserved αβTCR(+) T cell population that can swiftly produce large amounts of cytokines, thereby activating other leukocytes, including neutrophilic granulocytes (neutrophils). In this study, we investigated the reverse relationship, showing that high neutrophil concentrations suppress the iNKT cell response in mice and humans. Peripheral Vα14 iNKT cells from spontaneously neutrophilic mice produced reduced cytokines in response to the model iNKT cell Ag α-galactosyl ceramide and expressed lower amounts of the T-box transcription factor 21 and GATA3 transcription factor than did wild-type controls. This influence was extrinsic, as iNKT cell transcription factor expression in mixed chimeric mice depended on neutrophil count, not iNKT cell genotype. Transcription factor expression was also decreased in primary iNKT cells from the neutrophil-rich bone marrow compared with spleen in wild-type mice. In vitro, the function of both mouse and human iNKT cells was inhibited by coincubation with neutrophils. This required cell-cell contact with live neutrophils. Neutrophilic inflammation in experimental peritonitis in mice decreased iNKT cell T-box transcription factor 21 and GATA3 expression and α-galactosyl ceramide-induced cytokine production in vivo. This was reverted by blockade of neutrophil mobilization. Similarly, iNKT cells from the human peritoneal cavity expressed lower transcription factor levels during neutrophilic peritonitis. Our data reveal a novel regulatory axis whereby neutrophils reduce iNKT cell responses, which may be important in shaping the extent of inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.