Evidence map›Paper›PMID 22387474›Full record

GuidelineNeuroImage2013

Neuroimaging in aphasia treatment research: consensus and practical guidelines for data analysis.

Marcus Meinzer, Pélagie M Beeson, Stefano Cappa, Jenny Crinion, Swathi Kiran, Dorothee Saur, Todd Parrish, Bruce Crosson, Cynthia K Thompson, Neuroimaging in Aphasia Treatment Research Workshop

Erratum issued Registry-linked trialOpen access · greenAbstract readReviewPractice Guideline
In one paragraph

Guideline in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01927302 (The Center for the Neurobiology of Language Recovery), which is not on this map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01927302 nacompletednot on this map

The Center for the Neurobiology of Language Recovery (CNLR)

TypeinterventionalSponsorNorthwestern UniversityRan2013 to 2019Enrolled90ConditionsAphasia, Dysgraphia, Anomia, AgrammatismArmsTreatment Focusing on Naming Objects, Treatment Focusing on Improving Spelling Abilities, Treatment Focusing on Improving Sentence Processing, No Treatment
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 49 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. A Review on Treatment-Related Brain Changes in Aphasia.Neurobiology of language (Cambridge, Mass.) · 2020
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 4 countries.

Marcus MeinzerCharite Universitätsmedizin, Department of Neurology, Center for Stroke Research Berlin & Cluster of Excellence NeuroCure, Berlin, Germany. marcus.meinzer@charite.de
Pélagie M Beeson
Stefano Cappa
Jenny Crinion
Swathi Kiran
Dorothee Saur
Todd Parrish
Bruce Crosson
Cynthia K Thompson
Neuroimaging in Aphasia Treatment Research Workshop
Northwestern University · USUniversity of Florida · USBoston University · USLeipzig University · DEUniversity College London · GBUniversity of Arizona · USVita-Salute San Raffaele University · IT

Funding

Neurobiology of Language Recovery in Aphasia: Natural History and Treatment-Ind*P50DC012283 · NIDCD · NORTHWESTERN UNIVERSITY · PI THOMPSON, CYNTHIA K · 2013 to 2017
$11.7M
Neurolinguistic Investigations of Aphasia and RecoveryR01DC001948 · NIDCD · NORTHWESTERN UNIVERSITY · PI THOMPSON, CYNTHIA K · 1992 to 2021
$7.9M
Developing Evidence-Based Treatment for AgraphiaR01DC007646 · NIDCD · UNIVERSITY OF ARIZONA · PI BEESON, PELAGIE M · 2005 to 2015
$3.4M
Neural Correlates of Aphasia Treatment and Recovery: fMRI InvestigationsR01DC007213 · NIDCD · NORTHWESTERN UNIVERSITY · PI THOMPSON, CYNTHIA K · 2005 to 2009
$2.8M
Cognitive Mechanisms and Neural Substrates of Written Language ProcessingR01DC008286 · NIDCD · UNIVERSITY OF ARIZONA · PI RAPCSAK, STEVEN Z · 2006 to 2008
$940k
Treating Intention in Aphasia: Neuroplastic SubstratesR01DC007387 · NIDCD · UNIVERSITY OF FLORIDA · PI CROSSON, BRUCE A. · 2006 to 2008
$896k
An fMRI Model of Naming in Alzheimer's DiseaseR21DC009247 · NIDCD · UNIVERSITY OF FLORIDA · PI CROSSON, BRUCE A. · 2009 to 2010
$388k
Application of Multimodal Imaging Techniques to Examine Language Recovery in PostK18DC011517 · NIDCD · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI KIRAN, SWATHI · 2011 to 2012
$250k
Medical Research Council G0701888NIDCD NIH HHS DC007646NIDCD NIH HHS DC008286NIDCD NIH HHS K18 DC011517NIDCD NIH HHS P50 DC012283NIDCD NIH HHS R01 DC001948NIDCD NIH HHS R01 DC007213NIDCD NIH HHS R01DC007213NIDCD NIH HHS R01 DC007387NIDCD NIH HHS R01DC007387NIDCD NIH HHS R01 DC007646NIDCD NIH HHS R01 DC008286NIDCD NIH HHS R01DC01948NIDCD NIH HHS R21 DC009247NIDCD NIH HHS R21DC009247
6 · The paper itself

Abstract

Functional magnetic resonance imaging is the most widely used imaging technique to study treatment-induced recovery in post-stroke aphasia. The longitudinal design of such studies adds to the challenges researchers face when studying patient populations with brain damage in cross-sectional settings. The present review focuses on issues specifically relevant to neuroimaging data analysis in aphasia treatment research identified in discussions among international researchers at the Neuroimaging in Aphasia Treatment Research Workshop held at Northwestern University (Evanston, Illinois, USA). In particular, we aim to provide the reader with a critical review of unique problems related to the pre-processing, statistical modeling and interpretation of such data sets. Despite the fact that data analysis procedures critically depend on specific design features of a given study, we aim to discuss and communicate a basic set of practical guidelines that should be applicable to a wide range of studies and useful as a reference for researchers pursuing this line of research.

Indexed as

Data Interpretation, StatisticalAphasiaCerebrovascular CirculationConsensusHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingModels, StatisticalNeuroimagingRecovery of Function

Identifiers

PMID22387474
PMCPMC3416913
OpenAlexW2156626046

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.