ArticleMolecular and cellular endocrinology2012
Differential placental expression profile of human Growth Hormone/Chorionic Somatomammotropin genes in pregnancies with pre-eclampsia and gestational diabetes mellitus.
Article in Molecular and cellular endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Placental hormones, IGF-1, and early-life growth: endocrine links between birth size and infant metabolic programming-a systematic review.European journal of pediatrics · 2026Pooled it
- Pooled it
- Extensive load of somatic CNVs in the human placenta.Scientific reports · 2015Trial
- Gene regulation at the early human maternal-fetal interface.Nature reviews. Genetics · 2026Review
- Maternal Gestational Diabetes Impairs Fetoplacental Insulin-Induced Vasodilation via AKT/eNOS Pathway and Reduces Placental Efficiency.International journal of molecular sciences · 2025Article
- High-throughput mRNA sequencing of human placenta shows sex differences across gestation.Placenta · 2024Article
- Placental proteome in late‑onset of fetal growth restriction.Molecular medicine reports · 2022Article
- How Placenta Promotes the Successful Reproduction in High-Altitude Populations: A Transcriptome Comparison between Adaptation and Acclimatization.Molecular biology and evolution · 2022Article
- Prenatal health behaviours as predictors of human placental lactogen levels.Frontiers in endocrinology · 2022Article
- Network-based analysis of key regulatory genes implicated in Type 2 Diabetes Mellitus and Recurrent Miscarriages in Turner Syndrome.Scientific reports · 2021Article
- Changes in pregnancy-related serum biomarkers early in gestation are associated with later development of preeclampsia.PloS one · 2020Article
- H3K27 acetylation and gene expression analysis reveals differences in placental chromatin activity in fetal growth restriction.Clinical epigenetics · 2018Article
- Expression of placental regulatory genes is associated with fetal growth.Journal of perinatal medicine · 2017Article
- Whole-transcriptome analysis delineates the human placenta gene network and its associations with fetal growth.BMC genomics · 2017Article
- Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion.Development (Cambridge, England) · 2017Article
- Milk consumption during pregnancy increases birth weight, a risk factor for the development of diseases of civilization.Journal of translational medicine · 2015Review
- Myeloid decidual dendritic cells and immunoregulation of pregnancy: defective responsiveness to Coxiella burnetii and Brucella abortus.Frontiers in cellular and infection microbiology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The human GH/CSH cluster consisting of one pituitary-expressed (GH1) and four placenta-expressed loci has been implicated in maternal metabolic adaptation to pregnancy, regulation of intrauterine and postnatal growth. We investigated how the mRNA expression profile of placental GH2, CSH1 and CSH2 genes and their alternative transcripts correlates with maternal pre-eclampsia (PE) and/or gestational diabetes mellitus (GD). The expression of studied genes in PE placentas (n=17) compared to controls (n=17) exhibited a trend for reduced transcript levels. The alternative transcripts retaining intron 4, GH2-2 and CSH1-2 showed significantly reduced expression in PE cases without growth restriction (P=0.007, P=0.008, respectively). In maternal GD (n=23), a tendency of differential expression was detected only for the GH2 gene and in pregnancies with large-for-gestational-age newborns. Our results, together with those reported by others, are consistent with a pleiotropic effect of placental hGH/CSH genes at the maternal-fetal interface relating to the regulation of fetal growth and the risk of affected maternal metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.