ArticleMicron (Oxford, England : 1993)2012
Visualizing macromolecular complexes with in situ liquid scanning transmission electron microscopy.
Article in Micron (Oxford, England : 1993), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Exploring Biomineralization Processes Using In Situ Liquid Transmission Electron Microscopy: A Review.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Influence of the Electron Beam and the Choice of Heating Membrane on the Evolution of Si Nanowires' Morphology in In Situ TEM.Materials (Basel, Switzerland) · 2022Article
- Differentiating Trypanosoma cruzi in a Host Mammalian Cell Imaged in Aqueous Liquid by Atmospheric Scanning Electron Microscopy.Microbiology spectrum · 2022Article
- Liquid-phase ASEM imaging of cellular and structural details in cartilage and bone formed during endochondral ossification: Keap1-deficient osteomalacia.Scientific reports · 2021Article
- Pyrene Excimer-Based Fluorescent Labeling of Cysteines Brought into Close Proximity by Protein Dynamics: ASEM-Induced Thiol-Ene Click Reaction for High Spatial Resolution CLEM.International journal of molecular sciences · 2020Article
- Self-assembling peptides imaged by correlated liquid cell transmission electron microscopy and MALDI-imaging mass spectrometry.Nature communications · 2019Article
- Calcium phosphate mineralization in bone tissues directly observed in aqueous liquid by atmospheric SEM (ASEM) without staining: microfluidics crystallization chamber and immuno-EM.Scientific reports · 2019Article
- Polymerization-Induced Self-Assembly of Micelles Observed by Liquid Cell Transmission Electron Microscopy.ACS central science · 2018Article
- The role of electron irradiation history in liquid cell transmission electron microscopy.Science advances · 2018Article
- Detection of isolated protein-bound metal ions by single-particle cryo-STEM.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Studying Dynamic Processes of Nano-sized Objects in Liquid using Scanning Transmission Electron Microscopy.Journal of visualized experiments : JoVE · 2017Article
- Imaging of bacterial multicellular behaviour in biofilms in liquid by atmospheric scanning electron microscopy.Scientific reports · 2016Article
- A Structural Study of Escherichia coli Cells Using an In Situ Liquid Chamber TEM Technology.Journal of analytical methods in chemistry · 2015Article
- Correlative electron and fluorescence microscopy of magnetotactic bacteria in liquid: toward in vivo imaging.Scientific reports · 2014Article
- Dynamics of soft nanomaterials captured by transmission electron microscopy in liquid water.Journal of the American Chemical Society · 2014Article
- Simulating realistic imaging conditions for in situ liquid microscopy.Ultramicroscopy · 2013Article
- Ultrastructural analysis of nanogold-labeled cell surface microvilli in liquid by atmospheric scanning electron microscopy and their relevance in cell adhesion.International journal of molecular sciences · 2013Article
- Enabling direct nanoscale observations of biological reactions with dynamic TEM.Microscopy (Oxford, England) · 2013Review
- Direct in situ determination of the mechanisms controlling nanoparticle nucleation and growth.ACS nano · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
A central focus of biological research is understanding the structure/function relationship of macromolecular protein complexes. Yet conventional transmission electron microscopy techniques are limited to static observations. Here we present the first direct images of purified macromolecular protein complexes using in situ liquid scanning transmission electron microscopy. Our results establish the capability of this technique for visualizing the interface between biology and nanotechnology with high fidelity while also probing the interactions of biomolecules within solution. This method represents an important advancement towards allowing future high-resolution observations of biological processes and conformational dynamics in real-time.
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Registered trials
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