ReviewThe Journal of allergy and clinical immunology2012
Asthma outcomes: exacerbations.
Review in The Journal of allergy and clinical immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06385236 (Leveraging Pharmacogenomics in Asthma for Predication, Mechanism and Endotyping), which is not on this map. Cited by 168 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Leveraging Pharmacogenomics in Asthma for Predication, Mechanism and Endotyping
Who cites it
168 citing papers in PubMed, 7 syntheses or guidelines pooled it, 319 citations in OpenAlex.
- Applications of machine learning approaches for pediatric asthma exacerbation management: a systematic review.BMC medical informatics and decision making · 2025Pooled it
- Increased versus stable doses of inhaled corticosteroids for exacerbations of chronic asthma in adults and children.The Cochrane database of systematic reviews · 2022Pooled it
- A genome-wide association study of severe asthma exacerbations in Latino children and adolescents.The European respiratory journal · 2021Pooled it
- Antibiotics for exacerbations of asthma.The Cochrane database of systematic reviews · 2018Pooled it
- Pooled it
- Different oral corticosteroid regimens for acute asthma.The Cochrane database of systematic reviews · 2016Pooled it
- Report from the third international consensus meeting to harmonise core outcome measures for atopic eczema/dermatitis clinical trials (HOME).The British journal of dermatology · 2014Pooled it
- Comparative effectiveness of omalizumab, mepolizumab, and dupilumab in asthma: A target trial emulation.The Journal of allergy and clinical immunology · 2023Trial
- The nationwide retrospective cohort study by Health Insurance Review and Assessment Service proves that asthma management decreases the exacerbation risk of asthma.Scientific reports · 2021Trial
- Two regimens of dexamethasone versus prednisolone for acute exacerbations in asthmatic Egyptian children.European journal of hospital pharmacy : science and practice · 2020Trial
- Development and initial validation of the Asthma Severity Scoring System (ASSESS).The Journal of allergy and clinical immunology · 2020Trial
- Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation.The journal of allergy and clinical immunology. In practice · 2019Trial
- Use of Asthma APGAR Tools in Primary Care Practices: A Cluster-Randomized Controlled Trial.Annals of family medicine · 2018Trial
- Individualized therapy for persistent asthma in young children.The Journal of allergy and clinical immunology · 2016Trial
- Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations.The Journal of allergy and clinical immunology · 2015Trial
- Efficacy of acupuncture for chronic asthma: study protocol for a randomized controlled trial.Trials · 2015Trial
- Trial
- A Randomized, Double-Blind, Placebo-Controlled Trial of Escitalopram in Patients with Asthma and Major Depressive Disorder.The journal of allergy and clinical immunology. In practiceTrial
- Practice Variation in Management of Childhood Asthma Is Associated with Outcome Differences.The journal of allergy and clinical immunology. In practiceTrial
- Effect of IL-4RαR576 polymorphism on response to dupilumab in asthma, a genotype-stratified, randomized, placebo- controlled trial (IDEA trial): design, rationale, methods, strategies, and lessons learned.The Journal of asthma : official journal of the Association for the Care of Asthma · 2026Article
108 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundThe goals of asthma treatment include preventing recurrent exacerbations. Yet there is no consensus about the terminology for describing or defining "exacerbation" or about how to characterize an episode's severity.
objectiveNational Institutes of Health institutes and other federal agencies convened an expert group to propose how asthma exacerbation should be assessed as a standardized asthma outcome in future asthma clinical research studies.
methodsWe used comprehensive literature reviews and expert opinion to compile a list of asthma exacerbation outcomes and classified them as either core (required in future studies), supplemental (used according to study aims and standardized), or emerging (requiring validation and standardization). This work was discussed at a National Institutes of Health-organized workshop in March 2010 and finalized in September 2011.
resultsNo dominant definition of "exacerbation" was found. The most widely used definitions included 3 components, all related to treatment, rather than symptoms: (1) systemic use of corticosteroids, (2) asthma-specific emergency department visits or hospitalizations, and (3) use of short-acting β-agonists as quick-relief (sometimes referred to as "rescue" or "reliever") medications.
conclusionsThe working group participants propose that the definition of "asthma exacerbation" be "a worsening of asthma requiring the use of systemic corticosteroids to prevent a serious outcome." As core outcomes, they propose inclusion and separate reporting of several essential variables of an exacerbation. Furthermore, they propose the development of a standardized, component-based definition of "exacerbation" with clear thresholds of severity for each component.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.