Evidence map›Paper›PMID 22386471›Full record

ReviewPain2012

Pain, affective symptoms, and cognitive deficits in patients with cerebral dopamine dysfunction.

Johanna M Jarcho, Emeran A Mayer, Ziyue Karen Jiang, Natasha A Feier, Edythe D London

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pain, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 1 synthesis or guideline pooled it, 152 citations in OpenAlex.

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  20. Pain hypersensitivity in a pharmacological mouse model of attention-deficit/hyperactivity disorder.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Johanna M JarchoNational Institute of Mental Health, Bethesda, MD, USA Department of Medicine, Oppenheimer Family Center for Neurobiology of Stress, University of California, Los Angeles, CA, USA Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA Brain Research Institute, University of California, Los Angeles, CA, USA.
Emeran A Mayer
Ziyue Karen Jiang
Natasha A Feier
Edythe D London
University of California, Los Angeles · USNational Institute of Mental Health · US

Funding

Women's Health and Functional Visceral Disorders CenterP50DK064539 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 2002 to 2017
$17.5M
Neurobiological endophenotypes & gene-environment interactions in IC/PBS & in aU01DK082370 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUTCH, JASON J., MAYER, EMERAN A · 2008 to 2021
$9.2M
PERCEPTION AND MODULATION OF VISCERAL SENSATIONSR01DK048351 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 1996 to 2019
$8.2M
RESEARCH TRAINING: PSYCHOBIOLOGICAL SCIENCEST32MH017140 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEUCHTER, ANDREW F · 1985 to 2012
$3.2M
NIDDK NIH HHS DK 082370NIDDK NIH HHS DK 48351NIDDK NIH HHS DK 64531NIDDK NIH HHS P50 DK064539NIDDK NIH HHS R01 DK048351NIDDK NIH HHS U01 DK082370NIMH NIH HHS T32 MH017140
6 · The paper itself

Abstract

Converging preclinical, and human epidemiological, neuroimaging, and genetic evidence suggests a central role for dopamine neurotransmission in modulating pain perception and analgesia. Dysregulation in dopamine signaling may modulate the experience of pain both directly, by enhancing or diminishing the propagation of nociceptive signals, and indirectly, by influencing affective and cognitive processes, which affect the expectation, experience, and interpretation of nociceptive signals. Hypersensitivity to pain and high rates of comorbid chronic pain are common in disorders linked with deficits in dopamine system function, including disorders of mood and affect, substance abuse, and Parkinson disease. Hyposensitivity to pain, however, is common in patients with schizophrenia, which has been linked with excessive dopamine neurotransmission. Although patients are typically affected most by the primary symptoms of their disorders, alterations in pain perception may further increase the burden of their illness, compromising their quality of life. The present review focuses on this relationship, and discusses clinical and potential therapeutic implications for both patients with dopamine-related disorders and those with chronic pain syndromes.

Indexed as

Affective SymptomsAnimalsBrainCognition DisordersDopamineHumansMental DisordersPainSignal TransductionDopamine

Identifiers

PMID22386471
PMCPMC3816524
OpenAlexW2170447689

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.