ArticleCurrent biology : CB2012
Protein synthesis during sleep consolidates cortical plasticity in vivo.
Article in Current biology : CB, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
93 citing papers in PubMed, 166 citations in OpenAlex.
- Trial
- Review
- The myth of the metabolic baseline: sleep-wake cycles undermine a foundational assumption in organismal biology.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Circadian Regulation of Neuronal Membrane Capacitance-Mechanisms and Implications for Neural Computation and Behavior.International journal of molecular sciences · 2025Review
- Latent mechanisms of plasticity are upregulated during sleep.Current opinion in neurobiology · 2025Review
- Article
- eEF2K regulates pain through translational control of BDNF.Molecular cell · 2025Article
- Brief sleep disruption alters synaptic structures among hippocampal and neocortical somatostatin-expressing interneurons.bioRxiv : the preprint server for biology · 2025Article
- Revisiting brain gene expression changes and protein modifications tracking homeostatic sleep pressure.Npj biological timing and sleep · 2025Review
- Sleep Consolidation Potentiates Sensorimotor Adaptation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Restoration of locus coeruleus noradrenergic transmission during sleep.bioRxiv : the preprint server for biology · 2024Article
- The intersection of sleep and synaptic translation in synaptic plasticity deficits in neurodevelopmental disorders.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Review
- Sleep restores an optimal computational regime in cortical networks.Nature neuroscience · 2024Article
- Article
- Probing pathways by which rhynchophylline modifies sleep using spatial transcriptomics.Biology direct · 2023Article
- Enriched binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia.Communications biology · 2023Article
- Altered integration of excitatory inputs onto the basal dendrites of layer 5 pyramidal neurons in a mouse model of Fragile X syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Understanding Sleep Regulation in Normal and Pathological Conditions, and Why It Matters.Journal of Huntington's disease · 2023Review
- Increased rates of brain protein synthesis during [N1,N2] sleep: L-[1-Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- A short-term memory trace persists for days in the mouse hippocampus.Communications biology · 2022Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Sleep consolidates experience-dependent brain plasticity, but the precise cellular mechanisms mediating this process are unknown [1]. De novo cortical protein synthesis is one possible mechanism. In support of this hypothesis, sleep is associated with increased brain protein synthesis [2, 3] and transcription of messenger RNAs (mRNAs) involved in protein synthesis regulation [4, 5]. Protein synthesis in turn is critical for memory consolidation and persistent forms of plasticity in vitro and in vivo [6, 7]. However, it is unknown whether cortical protein synthesis in sleep serves similar functions. We investigated the role of protein synthesis in the sleep-dependent consolidation of a classic form of cortical plasticity in vivo (ocular dominance plasticity, ODP; [8, 9]) in the cat visual cortex. We show that intracortical inhibition of mammalian target of rapamycin (mTOR)-dependent protein synthesis during sleep abolishes consolidation but has no effect on plasticity induced during wakefulness. Sleep also promotes phosphorylation of protein synthesis regulators (i.e., 4E-BP1 and eEF2) and the translation (but not transcription) of key plasticity related mRNAs (ARC and BDNF). These findings show that sleep promotes cortical mRNA translation. Interruption of this process has functional consequences, because it abolishes the consolidation of experience in the cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.