ArticleBiophysical journal2012
Antibody-functionalized fluid-permeable surfaces for rolling cell capture at high flow rates.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Numerical Assessment of the Efficiency of a New Minimally Invasive Probe for the Isolation of Circulating Tumor Cells.International journal for numerical methods in biomedical engineering · 2025Article
- Circulating tumor cells clusters and their role in Breast cancer metastasis; a review of literature.Discover oncology · 2024Review
- Tangential Flow Microfiltration for Viral Separation and Concentration.Micromachines · 2019Article
- Microfluidics-enabled rapid manufacturing of hierarchical silica-magnetic microflower toward enhanced circulating tumor cell screening.Biomaterials science · 2018Article
- A Microfluidic Method for the Selection of Undifferentiated Human Embryonic Stem Cells andMicrofluidics and nanofluidics · 2015Article
- Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation.Lab on a chip · 2015Review
- Maximizing Fibroblast Adhesion on Protein-Coated Surfaces Using Microfluidic Cell Printing.RSC advances · 2015Article
- A radial flow microfluidic device for ultra-high-throughput affinity-based isolation of circulating tumor cells.Small (Weinheim an der Bergstrasse, Germany) · 2014Article
- Rare cell isolation and analysis in microfluidics.Lab on a chip · 2014Review
- Discontinuous nanoporous membranes reduce non-specific fouling for immunoaffinity cell capture.Small (Weinheim an der Bergstrasse, Germany) · 2013Article
- Advances in microfluidic cell separation and manipulation.Current opinion in chemical engineering · 2013Article
- Recent advances in microfluidic cell separations.The Analyst · 2013Review
- Selective individual primary cell capture using locally bio-functionalized micropores.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Adhesion-based cell capture on surfaces in microfluidic devices forms the basis of numerous biomedical diagnostics and in vitro assays. However, the performance of these platforms is partly limited by interfacial phenomena that occur at low Reynolds numbers. In contrast, cell homing to porous vasculature is highly effective in vivo during inflammation, stem cell trafficking, and cancer metastasis. Here, we show that a porous, fluid-permeable surface functionalized with cell-specific antibodies promotes efficient and selective cell capture in vitro. This architecture is advantageous due to enhanced transport as streamlines are diverted toward the surface. Moreover, specific cell-surface interactions are promoted due to reduced shear, allowing gentle cell rolling and arrest. Together, these synergistic effects enable highly effective cell capture at flow rates more than an order of magnitude larger than those provided by existing devices with solid surfaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.