ArticleCell stem cell2012
Genetic regulators of a pluripotent adult stem cell system in planarians identified by RNAi and clonal analysis.
Article in Cell stem cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
120 citing papers in PubMed, 215 citations in OpenAlex.
- Mapping the knowledge landscape of planarian regeneration: a century of bibliometric insights.Biology direct · 2026Article
- Single-cell transcriptomics and RNAi screening define a hierarchical program of planarian eye regeneration.Cell reports · 2026Article
- RoboA reinforces planarian stem cell fate through FoxA and Anosmin1a.Nature communications · 2026Article
- Metabolites produced by agat+ cells support regeneration in the planarian Schmidtea mediterranea.Developmental biology · 2026Article
- Insights into Human Ciliopathies: Gene Silencing ofmicroPublication biology · 2026Article
- A neuregulin-like ligand and EGF receptor underpinFrontiers in cellular and infection microbiology · 2026Article
- Developmental Toxicity of Ibrutinib: Insights from Stem Cell Dynamics and Neural Regeneration in Planarians.Biomolecules · 2025Article
- Article
- Pluripotent Stem Cell Plasticity is Sculpted by a Slit-Independent Robo Pathway in a Regenerative Animal.bioRxiv : the preprint server for biology · 2025Article
- Chromatin remodeling protein BPTF mediates chromatin accessibility at gene promoters in planarian stem cells.BMC genomics · 2025Article
- DjsoxP-1 and Djsox5 are essential for tissue homeostasis and regeneration in Dugesia japonica.Cell and tissue research · 2025Article
- Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians.Heliyon · 2025Review
- Systemic identification and characterization of the conserved core NuRD complex in planarian.Frontiers in aging · 2025Article
- Functions and applications of RNA interference and small regulatory RNAs.Acta biochimica et biophysica Sinica · 2024Review
- A transcription factor atlas of stem cell fate in planarians.Cell reports · 2024Article
- piRNA generation is associated with the pioneer round of translation in stem cells.Nucleic acids research · 2024Article
- MRLC controls apoptotic cell death and functions to regulate epidermal development during planarian regeneration and homeostasis.Cell proliferation · 2024Article
- Purification and transcriptomic characterization of proliferative cells ofFrontiers in parasitology · 2024Article
- Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the AnnelidBiology · 2023Article
- Fate specification is spatially intermingled across planarian stem cells.Nature communications · 2023Article
60 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Pluripotency is a central, well-studied feature of embryonic development, but the role of pluripotent cell regulation in somatic tissue regeneration remains poorly understood. In planarians, regeneration of entire animals from tissue fragments is promoted by the activity of adult pluripotent stem cells (cNeoblasts). We utilized transcriptional profiling to identify planarian genes expressed in adult proliferating, regenerative cells (neoblasts). We also developed quantitative clonal analysis methods for expansion and differentiation of cNeoblast descendants that, together with RNAi, revealed gene roles in stem cell biology. Genes encoding two zinc finger proteins, Vasa, a LIM domain protein, Sox and Jun-like transcription factors, two candidate RNA-binding proteins, a Setd8-like protein, and PRC2 (Polycomb) were required for proliferative expansion and/or differentiation of cNeoblast-derived clones. These findings suggest that planarian stem cells utilize molecular mechanisms found in germ cells and other pluripotent cell types and identify genetic regulators of the planarian stem cell system.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.