Where PI3K/Akt meets Smads: the crosstalk determines human embryonic stem cell fate.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

19 citing papers in PubMed.

1. Arctigenin fromNutrients · 2025
   Article
2. Fe-doped MOF nanoparticles: the LIFR and BMP4 dual-signaling pathways activated regulator for in vitro expansion of mouse embryonic stem cells.Materials today. Bio · 2025
   Article
3. CDCA8 promotes bladder cancer survival by stabilizing HIF1α expression under hypoxia.Cell death & disease · 2023
   Article
4. Mesenchymal Stem Cell Derived Exosomes Therapy in Diabetic Wound Repair.International journal of nanomedicine · 2023
   Review
5. High yield engineered nanovesicles from ADSC with enriched miR-21-5p promote angiogenesis in adipose tissue regeneration.Biomaterials research · 2022
   Article
6. Transcriptomic Analysis of Naïve Human Embryonic Stem Cells Cultured in Three-Dimensional PEG Scaffolds.Biomolecules · 2020
   Article
7. Transforming growth factor-β (TGF-β)-induced up-regulation of TGF-β receptors at the cell surface amplifies the TGF-β response.The Journal of biological chemistry · 2019
   Article
8. Enhancer Chromatin and 3D Genome Architecture Changes from Naive to Primed Human Embryonic Stem Cell States.Stem cell reports · 2019
   Article
9. Phosphoinositide 3 Kinase Signaling in Human Stem Cells from Reprogramming to Differentiation: A Tale in Cytoplasmic and Nuclear Compartments.International journal of molecular sciences · 2019
   Review
10. SMAD family member 3 (SMAD3) and SMAD4 repress HIF2α-dependent iron-regulatory genes.The Journal of biological chemistry · 2019
    Article
11. Targeted gene silencing in human embryonic stem cells using cell-penetrating peptide PepFect 14.Stem cell research & therapy · 2019
    Article
12. Transcriptome variations among human embryonic stem cell lines are associated with their differentiation propensity.PloS one · 2018
    Article
13. CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency.Cell death and differentiation · 2017
    Article
14. Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/β-catenin pathway to enhance the stemness of gastric cancer.Scientific reports · 2016
    Article
15. Correlation of GOLPH3 Gene with Wnt Signaling Pathway in Human Colon Cancer Cells.Journal of Cancer · 2016
    Article
16. PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation.Nature communications · 2015
    Article
17. MiR-223 regulates human embryonic stem cell differentiation by targeting the IGF-1R/Akt signaling pathway.PloS one · 2013
    Article
18. Continuous hypoxic culturing of human embryonic stem cells enhances SSEA-3 and MYC levels.PloS one · 2013
    Article
19. Exosomes derived from autologous dermal fibroblasts promote diabetic cutaneous wound healing through the Akt/β-catenin pathway.Cell cycle (Georgetown, Tex.)
    Article

Corrections and comments

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  Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation.2012

Authors and funding

3 authors.

Funding

Abstract