ArticleThe Kaohsiung journal of medical sciences2012
Overexpression of annexin 1 in the development and differentiation of urothelial carcinoma.
Article in The Kaohsiung journal of medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Annexin A1 promotes the progression of bladder cancer via regulating EGFR signaling pathway.Cancer cell international · 2022Article
- Annexin A8 regulated by lncRNA-TUG1/miR-140-3p axis promotes bladder cancer progression and metastasis.Molecular therapy oncolytics · 2021Article
- Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation.Cell · 2018Article
- Correlation of ANXA1 expression with drug resistance and relapse in bladder cancer.International journal of clinical and experimental pathology · 2014Article
- Deregulation of annexin-A1 and galectin-1 expression in precancerous gastric lesions: intestinal metaplasia and gastric ulcer.Mediators of inflammation · 2014Article
- Expression of annexin-A1 and galectin-1 anti-inflammatory proteins and mRNA in chronic gastritis and gastric cancer.Mediators of inflammation · 2013Article
- Annexin 1 and its evolving role in systemic carcinogenesis besides its role in the pathogenesis of breast carcinomas.American journal of cancer research · 2012Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
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Abstract
This study investigates the expression of annexin 1 in urothelial carcinoma (UC) and its relation with clinicopathologic factors, and evaluates its potential clinical significance. Annexin 1 expression was analyzed by immunohistochemical staining with manual tissue microarrays and Western blot in UC. Immunohistochemical analysis of UC in tissue microarrays showed that annexin 1 protein was 76.5% (150/196) positive, which was markedly increased compared with that in the normal urothelium 20.8% (5/24) (p < 0.01). In addition, the positive expression rate of annexin 1 was higher in the high-grade UC (81.7%; 143/175) than in the low-grade UC (33.3%; 7/21). Western blot revealed that the expression of annexin 1 was low in low-grade UC, and markedly increased in high-grade UC. In conclusion, annexin 1 overexpression is observed in UC, which suggests it may be associated with tumorigenesis and its expression correlates with the differentiation of UC.
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