ArticleCardiovascular diabetology2012
A retrospective analysis of amputation rates in diabetic patients: can lower extremity amputations be further prevented?
Article in Cardiovascular diabetology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Platelet-rich plasma for the treatment of diabetic foot ulcer: a systematic review.Frontiers in endocrinology · 2023Pooled it
- A systematic review describing incidence rate and prevalence of dysvascular partial foot amputation; how both have changed over time and compare to transtibial amputation.Systematic reviews · 2017Pooled it
- Systolic blood pressure variability and lower extremity amputation in a non-elderly population with diabetes.Diabetes research and clinical practice · 2016Trial
- Engineering-based statistical analysis of amputation prevalence and the impact of contributing factors in 4 Iraqi cities (1980-2024).Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026Article
- Current and Future Directions in Fluorescence Imaging-Guided Debridement.Advances in wound care · 2025Review
- Effects of different treatment measures on the efficacy of diabetic foot ulcers: a network meta-analysis.Frontiers in endocrinology · 2024Article
- The International Working Group on the Diabetic Foot: Stories and Numbers Behind Three Decades of Evidence-Based Guidelines for the Management of Diabetes-Related Foot Disease.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024Article
- Point-of-care fluorescence imaging reveals extent of bacterial load in diabetic foot ulcers.International wound journal · 2023Article
- Diabetic wounds and artificial intelligence: A mini-review.World journal of clinical cases · 2023Review
- Article
- Clinical validation of an artificial intelligence-enabled wound imaging mobile application in diabetic foot ulcers.International wound journal · 2022Article
- Application of Topical Sucralfate and Topical Platelet-Rich Plasma Improves Wound Healing in Diabetic Ulcer Rats Wound Model.Journal of experimental pharmacology · 2021Article
- Association between glucose variation and lower extremity amputation incidence in individuals with type 2 diabetes: a nationwide retrospective cohort study.Diabetologia · 2020Article
- Factors associated with lower-extremity amputation in patients with diabetic foot ulcers in a Chinese tertiary care hospital.International wound journal · 2019Article
- Cytokine production capabilities of human primary monocyte-derived macrophages from patients with diabetes mellitus type 2 with and without diabetic peripheral neuropathy.Journal of pain research · 2019Article
- Article
- A Perioperative Approach to Increase Limb Salvage When Treating Foot Ulcers in Patients With Diabetes.AORN journal · 2018Article
- Diabetes-related foot disorders among adult Ghanaians.Diabetic foot & ankle · 2018Article
- Predictors of major lower limb amputation in type 2 diabetic patients referred for hospital care with diabetic foot syndrome.Diabetes, metabolic syndrome and obesity : targets and therapy · 2018Article
- Redefined clinical spectra of diabetic foot syndrome.Vascular health and risk management · 2018Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLower extremity amputations are costly and debilitating complications in patients with diabetes mellitus (DM). Our aim was to investigate changes in the amputation rate in patients with DM at the Karolinska University Hospital in Solna (KS) following the introduction of consensus guidelines for treatment and prevention of diabetic foot complications, and to identify risk groups of lower extremity amputations that should be targeted for preventive treatment.
methods150 diabetic and 191 nondiabetic patients were amputated at KS between 2000 and 2006; of these 102 diabetic and 99 nondiabetic patients belonged to the catchment area of KS. 21 diabetic patients who belonged to KS catchment area were amputated at Danderyd University Hospital. All patients' case reports were searched for diagnoses of diabetes, vascular disorders, kidney disorders, and ulcer infections of the foot.
resultsThere was a 60% reduction in the rate of amputations performed above the ankle in patients with DM during the study period. Patients with DM who underwent amputations were more commonly affected by foot infections and kidney disorders compared to the nondiabetic control group. Women with DM were 10 years older than the men when amputated, whereas men with DM underwent more multiple amputations and had more foot infections compared to the women. 88% of all diabetes-related amputations were preceded by foot ulcers. Only 30% of the patients had been referred to the multidisciplinary foot team prior to the decision of amputation.
conclusionsThese findings indicate a reduced rate of major amputations in diabetic patients, which suggests an implementation of the consensus guidelines of foot care. We also propose further reduced amputation rates if patients with an increased risk of future amputation (i.e. male sex, kidney disease) are identified and offered preventive treatment early.
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