ArticleJournal of the American Chemical Society2012
Photoswitchable nanoparticles for triggered tissue penetration and drug delivery.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed.
- Hollow-core polydopamine nanocarriers for ultrasound-enhanced drug delivery.Nanoscale horizons · 2026Article
- An automated illumination system for high-throughput photopharmacology studies: a case study of ROS-sensitive Zn- and Pd-phthalocyanine-loaded liposomes.The Analyst · 2025Article
- Targeted Phototriggered and pH-Responsive Micellar Cancer Drug Delivery System with Real-Time Monitoring through the NSET Mechanism.ACS applied bio materials · 2025Article
- Photoswitchable Merocyanine-Amphiphiles with Programmable Self-Assembly Times.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Azobenzene-Modified Temperature-Responsive Short Elastin-like Peptides for Photo-Controlled Phase Transition.ACS synthetic biology · 2025Article
- Transient infrared nanoscopy resolves the millisecond photoswitching dynamics of single lipid vesicles in water.Nature communications · 2025Article
- Unlocking Multimodal Nonlinear Microscopy for Deep-Tissue Imaging under Continuous-Wave Excitation with Tunable Upconverting Nanoparticles.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Present and future of cancer nano-immunotherapy: opportunities, obstacles and challenges.Molecular cancer · 2025Review
- Lipid-Coated Mesoporous Silica Particles for pH-Sensitive Tumor-Targeted Paclitaxel: Development, Characterization.Journal of Cancer · 2025Article
- Photoluminescence Switching in Quantum Dots Connected with Carboxylic Acid and Thiocarboxylic Acid End-Group Diarylethene Molecules.The journal of physical chemistry. C, Nanomaterials and interfaces · 2024Article
- MMP-2 Responsive Gold Nanorods Loaded with HSP-70 siRNA for Enhanced Photothermal Tumor Therapy.Molecular pharmaceutics · 2024Article
- Recent advances in shape memory scaffolds and regenerative outcomes.Biomedical engineering letters · 2024Review
- Flexible Fibrous Visible Light Sensors Based on Spiropyran for Wearable Devices, Electronic Skins, and Thermal Management Fabrics.Small science · 2024Article
- Designed to Degrade: Tailoring Polyesters for Circularity.Chemical reviews · 2024Review
- Stimulus-Responsive Hydrogels for Targeted Cancer Therapy.Gels (Basel, Switzerland) · 2024Review
- Light-responsive polymeric nanoparticles for retinal drug delivery: design cues, challenges and future perspectives.Heliyon · 2024Review
- Photoluminescence switching in quantum dots connected with fluorinated and hydrogenated photochromic molecules.RSC advances · 2024Article
- Structural Determinants of Stimuli-Responsiveness in Amphiphilic Macromolecular Nano-assemblies.Progress in polymer science · 2024Article
- Light-responsive biomaterials for ocular drug delivery.Drug delivery and translational research · 2023Review
- Phototriggered structures: Latest advances in biomedical applications.Acta pharmaceutica Sinica. B · 2023Review
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
We report a novel nanoparticulate drug delivery system that undergoes reversible volume change from 150 to 40 nm upon phototriggering with UV light. The volume change of these monodisperse nanoparticles comprising spiropyran, which undergoes reversible photoisomerization, and PEGylated lipid enables repetitive dosing from a single administration and enhances tissue penetration. The photoswitching allows particles to fluoresce and release drugs inside cells when illuminated with UV light. The mechanism of the light-induced size switching and triggered-release is studied. These particles provide spatiotemporal control of drug release and enhanced tissue penetration, useful properties in many disease states including cancer.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.