ArticlePhotochemistry and photobiology
Light-induced retinal degeneration is prevented by zinc, a component in the age-related eye disease study formulation.
Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Effects of a Red-Ginger-Based Multi-Nutrient Supplement on Optic Nerve Head Blood Flow in Open-Angle Glaucoma.Nutrients · 2026Article
- Zinc and animal health: an in-depth exploration of its role in physiological functions and regulatory molecular mechanisms.Journal of animal science and biotechnology · 2025Review
- Gut Microbiota Profiles in Myopes and Nonmyopes.Investigative ophthalmology & visual science · 2024Article
- Effect of Trace Metal Ions on the Conformational Stability of the Visual Photoreceptor Rhodopsin.International journal of molecular sciences · 2023Article
- Multifunctional role of zinc in human health: an update.EXCLI journal · 2023Review
- Redox Regulation of Signaling Complex between Caveolin-1 and Neuronal Calcium Sensor Recoverin.Biomolecules · 2022Article
- Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy-like retinal degeneration in a mouse model with iron overload.Aging cell · 2022Article
- Influence of gut microbiota on eye diseases: an overview.Annals of medicine · 2021Review
- Dietary Antioxidants in Age-Related Macular Degeneration and Glaucoma.Antioxidants (Basel, Switzerland) · 2021Review
- Zinc and Autophagy in Age-Related Macular Degeneration.International journal of molecular sciences · 2020Review
- The Role of Diet, Micronutrients and the Gut Microbiota in Age-Related Macular Degeneration: New Perspectives from the Gut⁻Retina Axis.Nutrients · 2018Review
- Nutritional and Lifestyle Interventions for Age-Related Macular Degeneration: A Review.Oxidative medicine and cellular longevity · 2017Review
- Enhancing the efficacy of AREDS antioxidants in light-induced retinal degeneration.Molecular vision · 2017Article
- Light-emitting-diode induced retinal damage and its wavelength dependencyInternational journal of ophthalmology · 2017Article
- Zinc and diabetic retinopathy.Journal of diabetes research · 2013Article
- Article
- Prevention of retinal light damage by zinc oxide combined with rosemary extract.Molecular vision · 2013Article
- Imaging free zinc levels in vivo - what can be learned?Inorganica chimica acta · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Mineral supplements are often included in multivitamin preparations because of their beneficial effects on metabolism. In this study, we used an animal model of light-induced retinal degeneration to test for photoreceptor cell protection by the essential trace element zinc. Rats were treated with various doses of zinc oxide and then exposed to intense visible light for as long as 8 h. Zinc treatment effectively prevented retinal light damage as determined by rhodopsin and retinal DNA recovery, histology and electrophoretic analysis of DNA damage and oxidized retinal proteins. Zinc oxide was particularly effective when given before light exposure and at doses two- to four-fold higher than recommended by the age-related eye disease study group. Treated rats exhibited higher serum and retinal pigment epithelial zinc levels and an altered retinal gene expression profile. Using an Ingenuity database, 512 genes with known functional annotations were found to be responsive to zinc supplementation, with 45% of these falling into a network related to cellular growth, proliferation, cell cycle and death. Although these data suggest an integrated and extensive regulatory response, zinc induced changes in gene expression also appear to enhance antioxidative capacity in retina and reduce oxidative damage arising from intense light exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.