ReviewCurrent HIV research2012
Potential mechanisms for increased HIV-1 transmission across the endocervical epithelium during C. trachomatis infection.
Review in Current HIV research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Global mapping of sexually transmitted Chlamydia trachomatis disease: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- UnveilingiScience · 2025Article
- Changes in Inflammatory Cytokine Levels in Rectal Mucosa Associated With Neisseria gonorrheae and/or Chlamydia trachomatis Infection and Treatment Among Men Who Have Sex With Men in Lima, Peru.The Journal of infectious diseases · 2024Article
- When Bacteria and Viruses Collide: A Tale ofViruses · 2023Review
- Ewe breed differences in the cervical transcriptome at the follicular phase of a synchronised oestrous cycle.BMC genomics · 2022Article
- Chlamydia trachomatis Enhances HIV Infection of Non-Activated PBMCs.EC microbiology · 2022Article
- Role of the human vaginal microbiota in the regulation of inflammation and sexually transmitted infection acquisition: Contribution of the non-human primate model to a better understanding?Frontiers in reproductive health · 2022Review
- Brazilian Protocol for Sexually Transmitted Infections, 2020: infections that cause cervicitis.Revista da Sociedade Brasileira de Medicina Tropical · 2021Article
- Article
- Fluorescence-Reported Allelic Exchange Mutagenesis-Mediated Gene Deletion Indicates a Requirement for Chlamydia trachomatis Tarp duringInfection and immunity · 2020Article
- Dissemination of Chlamydia from the reproductive tract to the gastro-intestinal tract occurs in stages and relies on Chlamydia transport by host cells.PLoS pathogens · 2019Article
- HIV Incidence Among Men Who Have Sex With Men After Diagnosis With Sexually Transmitted Infections.Sexually transmitted diseases · 2016Article
- Chlamydia trachomatis Infection of Endocervical Epithelial Cells Enhances Early HIV Transmission Events.PloS one · 2016Article
- The role of sex hormones in immune protection of the female reproductive tract.Nature reviews. Immunology · 2015Review
- Periluminal Distribution of HIV-Binding Target Cells and Gp340 in the Oral, Cervical and Sigmoid/Rectal Mucosae: A Mapping Study.PloS one · 2015Article
- Increased susceptibility to vaginal simian/human immunodeficiency virus transmission in pig-tailed macaques coinfected with Chlamydia trachomatis and Trichomonas vaginalis.The Journal of infectious diseases · 2014Article
- The role of sex hormones and the tissue environment in immune protection against HIV in the female reproductive tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2014Review
- Vaccine-induced HIV-1 envelope gp120 constant region 1-specific antibodies expose a CD4-inducible epitope and block the interaction of HIV-1 gp140 with galactosylceramide.Journal of virology · 2014Article
- Regulation of mucosal immunity in the female reproductive tract: the role of sex hormones in immune protection against sexually transmitted pathogens.American journal of reproductive immunology (New York, N.Y. : 1989) · 2014Review
- Mycoplasma genitalium promotes epithelial crossing and peripheral blood mononuclear cell infection by HIV-1.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Among the now pandemic sexually transmitted infections (STIs), Chlamydia trachomatis (C. trachomatis) is the predominant bacterial pathogen and human immunodeficiency virus type 1 (HIV-1) is the most lethal of the viral pathogens. The female genital tract is the primary site for heterosexual transmission of both C. trachomatis and HIV-1. Infection with C. trachomatis, and with a variety of other STIs, increases the risk for transmission of HIV-1, although the mechanisms for this finding remain unclear. We have used in vitro modeling to assess the mechanisms by which infection with genital C. trachomatis serovars might increase the transmission of HIV-1 across the female genital tract. C. trachomatis infection of an immortalized endocervical epithelial cell line (A2EN) increases the cell surface expression of the HIV-1 alternative primary receptor, galactosyl ceramide (GalCer), and of the HIV-1 co-receptors, CXCR4 and CCR5. C. trachomatis infection also increases the binding of HIV-1 to A2EN cells, and, subsequently, increases levels of virus in co-cultures of HIV-exposed A2EN and susceptible MT4-R5 T cells. Finally, in vivo endocervical cell sampling reveals a dramatic increase in the number of CD4+, CXCR4 and/or CCR5 positive T cell targets in the endocervix of C. trachomatis positive women when compared to those who are C. trachomatis negative. This combination of in vitro and in vivo results suggests several mechanisms for increased transmission of HIV-1 across the endocervices of C. trachomatis-infected women.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.