ArticleG3 (Bethesda, Md.)2012
A Whole-Chromosome Analysis of Meiotic Recombination in Drosophila melanogaster.
Article in G3 (Bethesda, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 68 citations in OpenAlex.
- Allelic gene conversion softens selective sweeps.Genetics · 2026Article
- Article
- Non-uniform chromosomal SNP density biases sites of meiotic crossovers in Drosophila melanogaster.G3 (Bethesda, Md.) · 2026Article
- Chromosome-specific differences in the recombination landscape of spontaneous meiotic nondisjunction.Genetics · 2026Article
- Chromosome-specific differences in the recombination landscape of spontaneous meiotic nondisjunction.bioRxiv : the preprint server for biology · 2026Article
- Non-uniform chromosomal SNP density biases sites of meiotic crossovers inbioRxiv : the preprint server for biology · 2025Article
- Polymorphic transposable elements contribute to variation in recombination landscapes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genomics of natural populations: gene conversion events reveal selected genes within the inversions of Drosophila pseudoobscura.G3 (Bethesda, Md.) · 2024Article
- Varying recombination landscapes between individuals are driven by polymorphic transposable elements.bioRxiv : the preprint server for biology · 2024Article
- Male-biased recombination at chromosome ends in a songbird revealed by precisely mapping crossover positions.G3 (Bethesda, Md.) · 2024Article
- Insights into non-crossover recombination from long-read sperm sequencing.bioRxiv : the preprint server for biology · 2024Article
- NCOurd: modelling length distributions of NCO events and gene conversion tracts.Bioinformatics (Oxford, England) · 2023Article
- Inversion invasions: when the genetic basis of local adaptation is concentrated within inversions in the face of gene flow.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Mutation accumulation opposes polymorphism: supergenes and the curious case of balanced lethals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- High-Resolution Estimates of Crossover and Noncrossover Recombination from a Captive Baboon Colony.Genome biology and evolution · 2022Article
- Deleterious mutation accumulation and the long-term fate of chromosomal inversions.PLoS genetics · 2021Article
- A pathway for error-free non-homologous end joining of resected meiotic double-strand breaks.Nucleic acids research · 2021Article
- Characterization of Non-selected Intermolecular Gene Conversion in the Polyploid HaloarchaeonFrontiers in microbiology · 2021Article
- The Theory and Applications of Measuring Broad-Range and Chromosome-Wide Recombination Rate from Allele Frequency Decay around a Selected Locus.Molecular biology and evolution · 2020Article
- Synaptonemal Complex-DeficientG3 (Bethesda, Md.) · 2020Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although traditional genetic assays have characterized the pattern of crossing over across the genome in Drosophila melanogaster, these assays could not precisely define the location of crossovers. Even less is known about the frequency and distribution of noncrossover gene conversion events. To assess the specific number and positions of both meiotic gene conversion and crossover events, we sequenced the genomes of male progeny from females heterozygous for 93,538 X chromosomal single-nucleotide and InDel polymorphisms. From the analysis of the 30 F1 hemizygous X chromosomes, we detected 15 crossover and 5 noncrossover gene conversion events. Taking into account the nonuniform distribution of polymorphism along the chromosome arm, we estimate that most oocytes experience 1 crossover event and 1.6 gene conversion events per X chromosome pair per meiosis. An extrapolation to the entire genome would predict approximately 5 crossover events and 8.6 conversion events per meiosis. Mean gene conversion tract lengths were estimated to be 476 base pairs, yielding a per nucleotide conversion rate of 0.86 × 10(-5) per meiosis. Both of these values are consistent with estimates of conversion frequency and tract length obtained from studies of rosy, the only gene for which gene conversion has been studied extensively in Drosophila. Motif-enrichment analysis revealed a GTGGAAA motif that was enriched near crossovers but not near gene conversions. The low-complexity and frequent occurrence of this motif may in part explain why, in contrast to mammalian systems, no meiotic crossover hotspots have been found in Drosophila.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.