ArticleG3 (Bethesda, Md.)2012
Extent With Modification: Leg Patterning in the Beetle Tribolium castaneum and the Evolution of Serial Homologs.
Article in G3 (Bethesda, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 70 citations in OpenAlex.
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- Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions.International journal of molecular sciences · 2023Review
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- Universal Features in Panarthropod Inter-Limb Coordination during Forward Walking.Integrative and comparative biology · 2021Review
- Genetical control of 2D pattern and depth of the primordial furrow that prefigures 3D shape of the rhinoceros beetle horn.Scientific reports · 2020Article
- Loss of intermediate regions of perpendicular body axes contributed to miniaturization of tardigrades.Proceedings. Biological sciences · 2020Article
- Shifting roles ofDevelopment (Cambridge, England) · 2019Article
- Genetic basis of species-specific genitalia reveals role in species diversification.Science advances · 2019Article
- The origins of novelty from within the confines of homology: the developmental evolution of the digging tibia of dung beetles.Proceedings. Biological sciences · 2019Article
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- A morphological novelty evolved by co-option of a reduced gene regulatory network and gene recruitment in a beetle.Proceedings. Biological sciences · 2018Article
- Cooption of an appendage-patterning gene cassette in the head segmentation of arachnids.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Enhancer identification and activity evaluation in the red flour beetle,Development (Cambridge, England) · 2018Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
Serial homologs are similar structures that develop at different positions within a body plan. These structures share some, but not all, aspects of developmental patterning, and their evolution is thought to be constrained by shared, pleiotropic gene functions. Here we describe the functions of 17 developmental genes during metamorphic development of the legs in the red flour beetle, Tribolium castaneum. This study provides informative comparisons between appendage development in Drosophila melanogaster and T. castaneum, between embryonic and adult development in T. castaneum, and between the development of serially homologous appendages. The leg gap genes Distal-less and dachshund are conserved in function. Notch signaling, the zinc-finger transcription factors related to odd-skipped, and bric-à-brac have conserved functions in promoting joint development. homothorax knockdown alters the identity of proximal leg segments but does not reduce growth. Lim1 is required for intermediate leg development but not distal tarsus and pretarsus development as in D. melanogaster. Development of the tarsus requires decapentaplegic, rotund, spineless, abrupt, and bric-à-brac and the EGF ligand encoded by Keren. Metathoracic legs of T. castaneum have four tarsomeres, whereas other legs have five. Patterns of gene activity in the tarsus suggest that patterning in the middle of the tarsal region, not the proximal- or distal-most areas, is responsible for this difference in segment number. Through comparisons with other recent studies of T. castaneum appendage development, we test hypotheses for the modularity or interdependence of development during evolution of serial homologs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.