ArticleG3 (Bethesda, Md.)2012
Accelerating the inbreeding of multi-parental recombinant inbred lines generated by sibling matings.
Article in G3 (Bethesda, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Celebrating discovery across the tree of life.G3 (Bethesda, Md.) · 2023Article
- Architecture of the outbred brown fat proteome defines regulators of metabolic physiology.Cell · 2022Article
- Article
- Construction, characteristics and high throughput molecular screening methodologies in some special breeding populations: a horticultural perspective.Journal of genetics · 2019Review
- Recursive Algorithms for Modeling Genomic Ancestral Origins in a Fixed Pedigree.G3 (Bethesda, Md.) · 2018Article
- High-Resolution Maps of Mouse Reference Populations.G3 (Bethesda, Md.) · 2017Article
- Genomes of the Mouse Collaborative Cross.Genetics · 2017Article
- Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross.Genetics · 2017Article
- Article
- A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2.PLoS genetics · 2015Article
- RNA-Seq alignment to individualized genomes improves transcript abundance estimates in multiparent populations.Genetics · 2014Article
- Status and access to the Collaborative Cross population.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- The genome architecture of the Collaborative Cross mouse genetic reference population.Genetics · 2012Article
- Ten years of the collaborative cross.G3 (Bethesda, Md.) · 2012Article
- Ten years of the Collaborative Cross.Genetics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inbred model organisms are powerful tools for genetic studies because they provide reproducible genomes for use in mapping and genetic manipulation. Generating inbred lines via sibling matings, however, is a costly undertaking that requires many successive generations of breeding, during which time many lines fail. We evaluated several approaches for accelerating inbreeding, including the systematic use of back-crosses and marker-assisted breeder selection, which we contrasted with randomized sib-matings. Using simulations, we explored several alternative breeder-selection methods and monitored the gain and loss of genetic diversity, measured by the number of recombination-induced founder intervals, as a function of generation. For each approach we simulated 100,000 independent lines to estimate distributions of generations to achieve full-fixation as well as to achieve a mean heterozygosity level equal to 20 generations of randomized sib-mating. Our analyses suggest that the number of generations to fully inbred status can be substantially reduced with minimal impact on genetic diversity through combinations of parental backcrossing and marker-assisted inbreeding. Although simulations do not consider all confounding factors underlying the inbreeding process, such as a loss of fecundity, our models suggest many viable alternatives for accelerating the inbreeding process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.