ArticleG3 (Bethesda, Md.)2012
Many Saccharomyces cerevisiae Cell Wall Protein Encoding Genes Are Coregulated by Mss11, but Cellular Adhesion Phenotypes Appear Only Flo Protein Dependent.
Article in G3 (Bethesda, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Discovery and functional characterization of endoglucanases fromApplied and environmental microbiology · 2026Article
- Regulatory role of Mss11 inFrontiers in cellular and infection microbiology · 2023Article
- Functional divergence of a global regulatory complex governing fungal filamentation.PLoS genetics · 2019Article
- Modifying Saccharomyces cerevisiae Adhesion Properties Regulates Yeast Ecosystem Dynamics.mSphere · 2018Article
- Article
- FLO5 gene controls flocculation phenotype and adhesive properties in a Saccharomyces cerevisiae sparkling wine strain.Scientific reports · 2017Article
- Whole-Genome Sequence and Variant Analysis of W303, a Widely-Used Strain ofG3 (Bethesda, Md.) · 2017Article
- Biotreatment of industrial olive washing water by synergetic association of microalgal-bacterial consortia in a photobioreactor.Environmental science and pollution research international · 2017Article
- IRES-dependent translated genes in fungi: computational prediction, phylogenetic conservation and functional association.BMC genomics · 2015Article
- Fine-tuning of histone H3 Lys4 methylation during pseudohyphal differentiation by the CDK submodule of RNA polymerase II.Genetics · 2015Article
- Co-Flocculation of Yeast Species, a New Mechanism to Govern Population Dynamics in Microbial Ecosystems.PloS one · 2015Article
- Comprehensive analysis of forty yeast microarray datasets reveals a novel subset of genes (APha-RiB) consistently negatively associated with ribosome biogenesis.BMC bioinformatics · 2014Article
- TEAK: topology enrichment analysis framework for detecting activated biological subpathways.Nucleic acids research · 2013Article
- Adhesion of yeast cells to different porous supports, stability of cell-carrier systems and formation of volatile by-products.World journal of microbiology & biotechnology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The outer cell wall of the yeast Saccharomyces cerevisiae serves as the interface with the surrounding environment and directly affects cell-cell and cell-surface interactions. Many of these interactions are facilitated by specific adhesins that belong to the Flo protein family. Flo mannoproteins have been implicated in phenotypes such as flocculation, substrate adhesion, biofilm formation, and pseudohyphal growth. Genetic data strongly suggest that individual Flo proteins are responsible for many specific cellular adhesion phenotypes. However, it remains unclear whether such phenotypes are determined solely by the nature of the expressed FLO genes or rather as the result of a combination of FLO gene expression and other cell wall properties and cell wall proteins. Mss11 has been shown to be a central element of FLO1 and FLO11 gene regulation and acts together with the cAMP-PKA-dependent transcription factor Flo8. Here we use genome-wide transcription analysis to identify genes that are directly or indirectly regulated by Mss11. Interestingly, many of these genes encode cell wall mannoproteins, in particular, members of the TIR and DAN families. To examine whether these genes play a role in the adhesion properties associated with Mss11 expression, we assessed deletion mutants of these genes in wild-type and flo11Δ genetic backgrounds. This analysis shows that only FLO genes, in particular FLO1/10/11, appear to significantly impact on such phenotypes. Thus adhesion-related phenotypes are primarily dependent on the balance of FLO gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.