ArticleG3 (Bethesda, Md.)2012
Strain Variation in the Transcriptome of the Dengue Fever Vector, Aedes aegypti.
Article in G3 (Bethesda, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- microRNA profiles and functions in mosquitoes.PLoS neglected tropical diseases · 2018Pooled it
- Integrated transcriptomic and variant analysis reveals molecular mechanisms of pyrethroid resistance in a genetically homogenized Cas9 strain of Aedes aegypti.Archives of toxicology · 2026Article
- Two avian Plasmodium species trigger different transcriptional responses on their vector Culex pipiens.Molecular ecology · 2025Article
- Deltamethrin Selection Drives Transcriptomic Changes in Detoxification, Immune, and Cuticle Genes inTropical medicine and infectious disease · 2025Article
- An 11-point time course midgut transcriptome across 72 h after bloodfeeding provides detailed temporal resolution of transcript expression in the arbovirus vector,Genome research · 2023Article
- Factors Affecting Arbovirus Midgut Escape in Mosquitoes.Pathogens (Basel, Switzerland) · 2023Review
- An E3 Ubiquitin Ligase Scaffolding Protein Is Proviral during Chikungunya Virus Infection in Aedes aegypti.Microbiology spectrum · 2022Article
- Vector competence of Aedes aegypti and screening for differentially expressed microRNAs exposed to Zika virus.Parasites & vectors · 2021Article
- Intraspecific Transcriptome Variation and Sex-Biased Expression in Anopheles arabiensis.Genome biology and evolution · 2021Article
- RNA-Seq analysis of blood meal induced gene-expression changes in Aedes aegypti ovaries.BMC genomics · 2021Article
- The mosquito protein AEG12 displays both cytolytic and antiviral properties via a common lipid transfer mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Transcriptome comparison of dengue-susceptible and -resistant field derived strains of Colombian Aedes aegypti using RNA-sequencing.Memorias do Instituto Oswaldo Cruz · 2021Article
- Transcriptomic Analysis ofInternational journal of molecular sciences · 2019Article
- Aedes Anphevirus: an Insect-Specific Virus Distributed Worldwide in Aedes aegypti Mosquitoes That Has Complex Interplays with Wolbachia and Dengue Virus Infection in Cells.Journal of virology · 2018Article
- Meta-Analysis ofFrontiers in bioengineering and biotechnology · 2017Article
- Apoptosis-related genes control autophagy and influence DENV-2 infection in the mosquito vector, Aedes aegypti.Insect biochemistry and molecular biology · 2016Article
- Genomic approaches for understanding dengue: insights from the virus, vector, and host.Genome biology · 2016Review
- Arbovirus-mosquito interactions: RNAi pathway.Current opinion in virology · 2015Review
- Mosquito immunity against arboviruses.Viruses · 2014Review
- Role of microRNAs in arbovirus/vector interactions.Viruses · 2014Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Studies of transcriptome dynamics provide a basis for understanding functional elements of the genome and the complexity of gene regulation. The dengue vector mosquito, Aedes aegypti, exhibits great adaptability to diverse ecological conditions, is phenotypically polymorphic, and shows variation in vectorial capacity to arboviruses. Previous genome sequencing showed richness in repetitive DNA and transposable elements that can contribute to genome plasticity. Population genetic studies revealed a varying degree of worldwide genetic polymorphism. However, the extent of functional genetic polymorphism across strains is unknown. The transcriptomes of three Ae. aegypti strains, Chetumal (CTM), Rexville D-Puerto Rico (Rex-D) and Liverpool (LVP), were compared. CTM is more susceptible than Rex- D to infection by dengue virus serotype 2. A total of 4188 transcripts exhibit either no or small variation (<2-fold) among sugar-fed samples of the three strains and between sugar- and blood-fed samples within each strain, corresponding most likely to genes encoding products necessary for vital functions. Transcripts enriched in blood-fed mosquitoes encode proteins associated with catalytic activities, molecular transport, metabolism of lipids, carbohydrates and amino acids, and functions related to blood digestion and the progression of the gonotropic cycle. Significant qualitative and quantitative differences were found in individual transcripts among strains including differential representation of paralogous gene products. The majority of immunity-associated transcripts decreased in accumulation after a bloodmeal and the results are discussed in relation to the different susceptibility of CTM and Rex-D mosquitoes to DENV2 infection.
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