ArticleG3 (Bethesda, Md.)2011
Generation of highly homogeneous strains of zebrafish through full sib-pair mating.
Article in G3 (Bethesda, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- Meioc-Piwil1 complexes regulate rRNA transcription for differentiation of spermatogonial stem cells.eLife · 2025Article
- Establishment and genetic characterization of zebrafish RW line.Scientific reports · 2025Article
- Establishment of a zebrafish inbred strain, M-AB, capable of regular breeding and genetic manipulation.Scientific reports · 2024Article
- Individual identification of inbred medaka based on characteristic melanophore spot patterns on the head.Scientific reports · 2023Article
- Mitochondrial network expansion and dynamic redistribution during islet morphogenesis in zebrafish larvae.FEBS letters · 2023Article
- The effects of intensive feeding on reproductive performance in laboratory zebrafish (Danio rerio).PloS one · 2022Article
- Sycp1 Is Not Required for Subtelomeric DNA Double-Strand Breaks but Is Required for Homologous Alignment in Zebrafish Spermatocytes.Frontiers in cell and developmental biology · 2021Article
- A fish is not a mouse: understanding differences in background genetics is critical for reproducibility.Lab animal · 2021Review
- Sycp2 is essential for synaptonemal complex assembly, early meiotic recombination and homologous pairing in zebrafish spermatocytes.PLoS genetics · 2020Article
- Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway.PLoS genetics · 2019Article
- Contested Paradigm in Raising Zebrafish (Danio rerio).Zebrafish · 2018Article
- Shifting Zebrafish Lethal Skeletal Mutant Penetrance by Progeny Testing.Journal of visualized experiments : JoVE · 2017Article
- Understanding the regulation of vertebrate hematopoiesis and blood disorders - big lessons from a small fish.FEBS letters · 2016Review
- A Novel Zebrafish ret Heterozygous Model of Hirschsprung Disease Identifies a Functional Role for mapk10 as a Modifier of Enteric Nervous System Phenotype Severity.PLoS genetics · 2016Article
- Production and verification of a 2Scientific reports · 2016Article
- The MHC class I genes of zebrafish.Developmental and comparative immunology · 2014Review
- The emerging use of zebrafish to model metabolic disease.Disease models & mechanisms · 2013Review
- Zebrafish model for allogeneic hematopoietic cell transplantation not requiring preconditioning.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Histocompatibility and hematopoietic transplantation in the zebrafish.Advances in hematology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetically homogeneous populations, such as inbred strains, are powerful experimental tools that are ideally suited for studying immunology, cancer, and genetics of complex traits. The zebrafish, Danio rerio, has been underutilized in these research areas because homogeneous strains of experimental fish have not been available in tractable condition. Here, we attempted to inbreed two zebrafish wild-type strains, Tübingen and India, through full sib-pair mating. Although the inbred Tübingen strain failed to thrive and was lost after 13 generations, an inbred India strain (IM) has been maintained successfully. The IM strain has endured 16 generations of inbreeding and has maintained a healthy condition. Two additional strains, IM12m and IM14m, were established as closed colonies from the branches of the IM strain. Genotype analyses using genetic markers revealed a dramatic decrease in polymorphisms (62% dropped to 5%) in both IM (generation 14) and the two closed colonies. This indicates a high level of homogeneity in these strains. Furthermore, scale transplantations between individuals within each strain were successful. These data suggest that extremely homogeneous zebrafish strains have been established, thereby creating a valuable resource for practical application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.