ArticleG3 (Bethesda, Md.)2011
SAD-3, a Putative Helicase Required for Meiotic Silencing by Unpaired DNA, Interacts with Other Components of the Silencing Machinery.
Article in G3 (Bethesda, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- An Hsp70 Chaperone Is Involved in Meiotic Silencing by Unpaired DNA.Epigenomes · 2026Article
- ARS2, a Cofactor of CBC, Promotes Meiotic Silencing by Unpaired DNA.Epigenomes · 2026Article
- Article
- A DEAD-box RNA helicase mediates meiotic silencing by unpaired DNA.G3 (Bethesda, Md.) · 2023Article
- Complete Genome Sequences and Genome-Wide Characterization ofMicrobiology spectrum · 2021Article
- Involvement of RNA granule proteins in meiotic silencing by unpaired DNA.G3 (Bethesda, Md.) · 2021Article
- Role of the Non-Canonical RNAi Pathway in the Antifungal Resistance and Virulence of Mucorales.Genes · 2021Review
- Opposing functions of Fng1 and the Rpd3 HDAC complex in H4 acetylation in Fusarium graminearum.PLoS genetics · 2020Article
- An NCBP3-Domain Protein Mediates Meiotic Silencing by Unpaired DNA.G3 (Bethesda, Md.) · 2020Article
- Conserved chromosomal functions of RNA interference.Nature reviews. Genetics · 2020Review
- Suppressors of Meiotic Silencing by Unpaired DNA.Non-coding RNA · 2019Article
- An RNA Recognition Motif-Containing Protein Functions in Meiotic Silencing by Unpaired DNA.G3 (Bethesda, Md.) · 2017Article
- Ascus dysgenesis in hybrid crosses of Neurospora and Sordaria (Sordariaceae).Journal of genetics · 2017Review
- Repeat-Induced Point Mutation and Other Genome Defense Mechanisms in Fungi.Microbiology spectrum · 2017Review
- The Nuclear Cap-Binding Complex Mediates Meiotic Silencing by Unpaired DNA.G3 (Bethesda, Md.) · 2017Article
- Endogenous Small RNA Mediates Meiotic Silencing of a Novel DNA Transposon.G3 (Bethesda, Md.) · 2015Article
- Lack of pairing during meiosis triggers multigenerational transgene silencing in Caenorhabditis elegans.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Complex formation of RNA silencing proteins in the perinuclear region of Neurospora crassa.Genetics · 2015Article
- Sex in the Mucoralean fungi.Mycoses · 2014Review
- Efficient detection of unpaired DNA requires a member of the rad54-like family of homologous recombination proteins.Genetics · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Neurospora crassa, genes lacking a pairing partner during meiosis are suppressed by a process known as meiotic silencing by unpaired DNA (MSUD). To identify novel MSUD components, we have developed a high-throughput reverse-genetic screen for use with the N. crassa knockout library. Here we describe the screening method and the characterization of a gene (sad-3) subsequently discovered. SAD-3 is a putative helicase required for MSUD and sexual spore production. It exists in a complex with other known MSUD proteins in the perinuclear region, a center for meiotic silencing activity. Orthologs of SAD-3 include Schizosaccharomyces pombe Hrr1, a helicase required for RNAi-induced heterochromatin formation. Both SAD-3 and Hrr1 interact with an RNA-directed RNA polymerase and an Argonaute, suggesting that certain aspects of silencing complex formation may be conserved between the two fungal species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.