ArticleG3 (Bethesda, Md.)2011
Multiple Quantitative Trait Loci Influence the Shape of a Male-Specific Genital Structure in Drosophila melanogaster.
Article in G3 (Bethesda, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- A developmental atlas of male terminalia across twelve species ofFrontiers in cell and developmental biology · 2024Article
- Interspecific introgression reveals a role of male genital morphology during the evolution of reproductive isolation in Drosophila.Evolution; international journal of organic evolution · 2021Article
- Unraveling the Genetic Basis for the Rapid Diversification of Male Genitalia between Drosophila Species.Molecular biology and evolution · 2021Article
- An Atlas of Transcription Factors Expressed in Male Pupal Terminalia ofG3 (Bethesda, Md.) · 2019Article
- Quantitative Trait Loci and Antagonistic Associations for Two Developmentally Related Traits in the Drosophila Head.Journal of insect science (Online) · 2017Article
- Genetic dissection of intraspecific variation in a male-specific sexual trait in Drosophila melanogaster.Heredity · 2016Article
- The Genetic Basis of Baculum Size and Shape Variation in Mice.G3 (Bethesda, Md.) · 2016Article
- Mapping QTL Contributing to Variation in Posterior Lobe Morphology between Strains of Drosophila melanogaster.PloS one · 2016Article
- A Major Locus Controls a Genital Shape Difference Involved in Reproductive Isolation Between Drosophila yakuba and Drosophila santomea.G3 (Bethesda, Md.) · 2015Article
- Multiple sexual selection pressures drive the rapid evolution of complex morphology in a male secondary genital structure.Ecology and evolution · 2015Article
- Article
- Copulatory wounding and traumatic insemination.Cold Spring Harbor perspectives in biology · 2015Review
- Genome-Wide Association Study on Male Genital Shape and Size in Drosophila melanogaster.PloS one · 2015Article
- Fine-mapping QTLs in advanced intercross lines and other outbred populations.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- The making of a pest: the evolution of a fruit-penetrating ovipositor in Drosophila suzukii and related species.Proceedings. Biological sciences · 2014Article
- Individual Genetic Contributions to Genital Shape Variation between Drosophila simulans and D. mauritiana.International journal of evolutionary biology · 2014Article
- Quantitative genetic insights into the coevolutionary dynamics of male and female genitalia.Proceedings. Biological sciences · 2013Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
The observation that male genitalia diverge more rapidly than other morphological traits during evolution is taxonomically widespread and likely due to some form of sexual selection. One way to elucidate the evolutionary forces acting on these traits is to detail the genetic architecture of variation both within and between species, a program of research that is considerably more tractable in a model system. Drosophila melanogaster and its sibling species, D. simulans, D. mauritiana, and D. sechellia, are morphologically distinguishable only by the shape of the posterior lobe, a male-specific elaboration of the genital arch. We extend earlier studies identifying quantitative trait loci (QTL) responsible for lobe divergence across species and report the first genetic dissection of lobe shape variation within a species. Using an advanced intercross mapping design, we identify three autosomal QTL contributing to the difference in lobe shape between a pair of D. melanogaster inbred lines. The QTL each contribute 4.6-10.7% to shape variation, and two show a significant epistatic interaction. Interestingly, these intraspecific QTL map to the same locations as interspecific lobe QTL, implying some shared genetic control of the trait within and between species. As a first step toward a mechanistic understanding of natural lobe shape variation, we find an association between our QTL data and a set of genes that show sex-biased expression in the developing genital imaginal disc (the precursor of the adult genitalia). These genes are good candidates to harbor naturally segregating polymorphisms contributing to posterior lobe shape.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.