ArticlePloS one2012
Expression of high-affinity IgE receptor on human peripheral blood dendritic cells in children.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Reduced Type-I Interferon by Plasmacytoid Dendritic Cells and Asthma in School-Aged Children.Allergy · 2026Article
- Histamine-induced RPS6 phosphorylation in dendritic cells is associated with the severity of peanut allergic reactions.JCI insight · 2025Article
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- Post-viral atopic airway disease: pathogenesis and potential avenues for intervention.Expert review of clinical immunology · 2019Review
- Respiratory viral infections and atopic development: From possible mechanisms to advances in treatment.European journal of immunology · 2018Review
- POL7085 or anti-CCL28 treatment inhibits development of post-paramyxoviral airway disease.Immunity, inflammation and disease · 2017Article
- Eosinophilic esophagitis: published evidences for disease subtypes, indications for patient subpopulations, and how to translate patient observations to murine experimental models.The World Allergy Organization journal · 2016Review
- Functions of dendritic-cell-bound IgE in allergy.Molecular immunology · 2015Review
- The role of FcεRI expressed in dendritic cells and monocytes.Cellular and molecular life sciences : CMLS · 2015Review
- Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites.Mucosal immunology · 2015Article
- Serum IgE clearance is facilitated by human FcεRI internalization.The Journal of clinical investigation · 2014Article
- Accumulation of BDCA1⁺ dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma.PloS one · 2014Article
- Antigen cross-presentation of immune complexes.Frontiers in immunology · 2014Review
- Article
- Role of viruses in the development of atopic disease in pediatric patients.Current allergy and asthma reports · 2012Review
- Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens.The Journal of clinical investigation · 2012Review
- Dendritic cells, viruses, and the development of atopic disease.Journal of allergy · 2012Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundIn a mouse model of viral induced atopic disease, expression of FcεRI on dendritic cells is critical. While adult human conventional (cDC) and plasmacytoid (pDC) dendritic cells have been shown to express FcεRI, it is not known if this receptor is expressed in childhood and how its expression is governed by IgE.
methodsFollowing informed consent of subjects (n = 27, aged 12-188 months), peripheral blood was stained for surface expression of CD19, ILT7, CD1c, IgE, FcεRI and analyzed by flow cytometry (cDC: CD19(-) ILT7(-) CD1c(+); pDC: CD19(-) ILT7(+) CD1c(-)). Total and specific serum IgE levels to food and inhalant allergens were determined by ImmunoCAP, and the relationship between FcεRI expression on dendritic cells and sensitization, free IgE, cell bound IgE, and age was determined.
resultsIndependent of sensitization status, FcεRI expression was noted on cDC and pDC as early as 12 months of age. Serum IgE level correlated with expression of FcεRI on cDC, but not pDC. Based on the concentration of IgE, a complex relationship was found between surface bound IgE and expression of FcεRI on cDC. pDC exhibited a linear relationship of FcεRI expression and bound IgE that was consistent through all IgE concentrations.
conclusionsIn children, FcεRI expression on cDC and pDC is modulated differently by serum and cell bound IgE. IgE governance of FcεRI expression on cDC depends upon a complex relationship. Further studies are needed to determine the functional roles of FcεRI on cDC and pDC.
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