ArticlePloS one2012
First dating of a recombination event in mammalian tick-borne flaviviruses.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Evidence for Powassan virus deletions and defective RNA in field-collected ticks.Journal of virology · 2026Article
- Suspected tick-borne flavivirus meningoencephalomyelitis in dogs from the UK: six cases (2021).The Journal of small animal practice · 2024Article
- The Baikal subtype of tick-borne encephalitis virus is evident of recombination between Siberian and Far-Eastern subtypes.PLoS neglected tropical diseases · 2023Article
- The recombinogenic history of turnip mosaic potyvirus reveals its introduction to Japan in the 19th century.Virus evolution · 2022Article
- TBEV Subtyping in Terms of Genetic Distance.Viruses · 2020Article
- Population genomics of louping ill virus provide new insights into the evolution of tick-borne flaviviruses.PLoS neglected tropical diseases · 2020Article
- Intragenic recombination influences rotavirus diversity and evolution.Virus evolution · 2020Article
- Review
- The Role of Mammalian Reservoir Hosts in Tick-Borne Flavivirus Biology.Frontiers in cellular and infection microbiology · 2018Review
- Recombinant domains III of Tick-Borne Encephalitis Virus envelope protein in combination with dextran and CpGs induce immune response and partial protectiveness against TBE virus infection in mice.BMC infectious diseases · 2016Article
- Revisiting Recombination Signal in the Tick-Borne Encephalitis Virus: A Simulation Approach.PloS one · 2016Article
- Tick-borne encephalitis virus subtypes emerged through rapid vector switches rather than gradual evolution.Ecology and evolution · 2014Article
- Louping ill virus: an endemic tick-borne disease of Great Britain.The Journal of general virology · 2014Review
- Tick-borne encephalitis virus sequenced directly from questing and blood-feeding ticks reveals quasispecies variance.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian tick-borne flavivirus group (MTBFG) contains viruses associated with important human and animal diseases such as encephalitis and hemorrhagic fever. In contrast to mosquito-borne flaviviruses where recombination events are frequent, the evolutionary dynamic within the MTBFG was believed to be essentially clonal. This assumption was challenged with the recent report of several homologous recombinations within the Tick-borne encephalitis virus (TBEV). We performed a thorough analysis of publicly available genomes in this group and found no compelling evidence for the previously identified recombinations. However, our results show for the first time that demonstrable recombination (i.e., with large statistical support and strong phylogenetic evidences) has occurred in the MTBFG, more specifically within the Louping ill virus lineage. Putative parents, recombinant strains and breakpoints were further tested for statistical significance using phylogenetic methods. We investigated the time of divergence between the recombinant and parental strains in a Bayesian framework. The recombination was estimated to have occurred during a window of 282 to 76 years before the present. By unravelling the temporal setting of the event, we adduce hypotheses about the ecological conditions that could account for the observed recombination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.