ArticlePloS one2012
Structural diversity in bacterial ribosomes: mycobacterial 70S ribosome structure reveals novel features.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Bacterial ribosome heterogeneity facilitates rapid response to stress.Journal of bacteriology · 2025Review
- Cryo- EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH.Nature communications · 2024Article
- Looking through the Lens of the Ribosome Biogenesis Evolutionary History: Possible Implications for Archaeal Phylogeny and Eukaryogenesis.Molecular biology and evolution · 2022Article
- Cryo-electron microscopy visualization of a large insertion in the 5S ribosomal RNA of the extremely halophilic archaeon Halococcus morrhuae.FEBS open bio · 2020Article
- Translational regulation in mycobacteria and its implications for pathogenicity.Nucleic acids research · 2018Review
- Cryo-EM structure of Mycobacterium smegmatis ribosome reveals two unidentified ribosomal proteins close to the functional centers.Protein & cell · 2018Article
- Article
- PdtaS Deficiency Affects Resistance of Mycobacteria to Ribosome Targeting Antibiotics.Frontiers in microbiology · 2017Article
- Article
- Leaderless Transcripts and Small Proteins Are Common Features of the Mycobacterial Translational Landscape.PLoS genetics · 2015Article
- Structure of Ribosomal Silencing Factor Bound to Mycobacterium tuberculosis Ribosome.Structure (London, England : 1993) · 2015Article
- Genome-wide transcription analyses in Mycobacterium tuberculosis treated with lupulone.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014Article
- One core, two shells: bacterial and eukaryotic ribosomes.Nature structural & molecular biology · 2012Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we present analysis of a 3D cryo-EM map of the 70S ribosome from Mycobacterium smegmatis, a saprophytic cousin of the etiological agent of tuberculosis in humans, Mycobacterium tuberculosis. In comparison with the 3D structures of other prokaryotic ribosomes, the density map of the M. smegmatis 70S ribosome reveals unique structural features and their relative orientations in the ribosome. Dramatic changes in the periphery due to additional rRNA segments and extra domains of some of the peripheral ribosomal proteins like S3, S5, S16, L17, L25, are evident. One of the most notable features appears in the large subunit near L1 stalk as a long helical structure next to helix 54 of the 23S rRNA. The sharp upper end of this structure is located in the vicinity of the mRNA exit channel. Although the M. smegmatis 70S ribosome possesses conserved core structure of bacterial ribosome, the new structural features, unveiled in this study, demonstrates diversity in the 3D architecture of bacterial ribosomes. We postulate that the prominent helical structure related to the 23S rRNA actively participates in the mechanisms of translation in mycobacteria.
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