ArticlePloS one2012
Hemodialysis removes uremic toxins that alter the biological actions of endothelial cells.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Autophagy and oxidative stress modulation mediate Bortezomib resistance in prostate cancer.PloS one · 2024Article
- Secretory activity of the coronary artery endothelial cells in conditions of the peritoneal dialysis.Renal failure · 2022Article
- Uremic serum induces prothrombotic changes in venous endothelial cells and inflammatory changes in aortic endothelial cells.Renal failure · 2021Article
- Review
- GSTM1 Modulates Expression of Endothelial Adhesion Molecules in Uremic Milieu.Oxidative medicine and cellular longevity · 2021Article
- Most exposed: the endothelium in chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Review
- Uremic Toxins and Vascular Dysfunction.Toxins · 2020Review
- Identifying cardiovascular risk factors that impact cerebrovascular reactivity: An ASL MRI study.Journal of magnetic resonance imaging : JMRI · 2020Article
- Uremic Serum Induces Inflammation in Cultured Human Endothelial Cells and Triggers Vascular Repair Mechanisms.Inflammation · 2019Article
- Citrate anion improves chronic dialysis efficacy, reduces systemic inflammation and prevents Chemerin-mediated microvascular injury.Scientific reports · 2019Article
- Effect of blood purification on serum miR-126 and VEGF levels in the process of atherosclerosis in uremic patients under maintenance hemodialysis.The Kaohsiung journal of medical sciences · 2018Article
- Decreases in plasma MMP-2/TIMP-2 and MMP-9/TIMP-1 ratios in uremic patients during hemodialysis.Clinical and experimental nephrology · 2016Article
- Impaired renal function is associated with brain atrophy and poststroke cognitive decline.Neurology · 2016Article
- Article
- Effect of uraemia on endothelial cell damage is mediated by the integrin linked kinase pathway.The Journal of physiology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic kidney disease is linked to systemic inflammation and to an increased risk of ischemic heart disease and atherosclerosis. Endothelial dysfunction associates with hypertension and vascular disease in the presence of chronic kidney disease but the mechanisms that regulate the activation of the endothelium at the early stages of the disease, before systemic inflammation is established remain obscure. In the present study we investigated the effect of serum derived from patients with chronic kidney disease either before or after hemodialysis on the activation of human endothelial cells in vitro, as an attempt to define the overall effect of uremic toxins at the early stages of endothelial dysfunction. Our results argue that uremic toxins alter the biological actions of endothelial cells and the remodelling of the extracellular matrix before signs of systemic inflammatory responses are observed. This study further elucidates the early events of endothelial dysfunction during toxic uremia conditions allowing more complete understanding of the molecular events as well as their sequence during progressive renal failure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.