ArticlePLoS genetics2012
Cell lineage analysis of the mammalian female germline.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 75 citations in OpenAlex.
- Tracking Somatic Mutations for Lineage Reconstruction.Methods in molecular biology (Clifton, N.J.) · 2025Article
- High-fidelity, large-scale targeted profiling of microsatellites.Genome research · 2024Article
- Review
- Making a good egg: human oocyte health, aging, and in vitro development.Physiological reviews · 2023Review
- Best Practices in Designing, Sequencing, and Identifying Random DNA Barcodes.Journal of molecular evolution · 2023Review
- In-vivo oogenesis of oogonial and mesenchymal stem cells seeded in transplanted ovarian extracellular matrix.Journal of ovarian research · 2023Article
- Early embryonic mutations reveal dynamics of somatic and germ cell lineages in mice.Genome research · 2022Article
- Review
- Alignment of Cell Lineage Trees Elucidates Genetic Programs for the Development and Evolution of Cell Types.iScience · 2020Article
- Unravelling cellular relationships during development and regeneration using genetic lineage tracing.Nature reviews. Molecular cell biology · 2019Review
- Autologous activated platelet-rich plasma injection into adult human ovary tissue: molecular mechanism, analysis, and discussion of reproductive response.Bioscience reports · 2019Review
- Lineage Tracing: Computational Reconstruction Goes Beyond the Limit of Imaging.Molecules and cells · 2019Review
- Role of stem cells in fertility preservation: current insights.Stem cells and cloning : advances and applications · 2019Article
- Heterogeneity of primordial germ cells.Current topics in developmental biology · 2019Review
- Initial characterisation of adult human ovarian cell populations isolated by DDX4 expression and aldehyde dehydrogenase activity.Scientific reports · 2018Article
- The Human Cell Atlas.eLife · 2017Article
- Quantitative Analysis of Synthetic Cell Lineage Tracing Using Nuclease Barcoding.ACS synthetic biology · 2017Article
- Building a lineage from single cells: genetic techniques for cell lineage tracking.Nature reviews. Genetics · 2017Review
- Review
- Mesenchymal Stem Cells in Restoration of Fertility at Experimental Pelvic Inflammatory Disease.Stem cells international · 2017Article
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fundamental aspects of embryonic and post-natal development, including maintenance of the mammalian female germline, are largely unknown. Here we employ a retrospective, phylogenetic-based method for reconstructing cell lineage trees utilizing somatic mutations accumulated in microsatellites, to study female germline dynamics in mice. Reconstructed cell lineage trees can be used to estimate lineage relationships between different cell types, as well as cell depth (number of cell divisions since the zygote). We show that, in the reconstructed mouse cell lineage trees, oocytes form clusters that are separate from hematopoietic and mesenchymal stem cells, both in young and old mice, indicating that these populations belong to distinct lineages. Furthermore, while cumulus cells sampled from different ovarian follicles are distinctly clustered on the reconstructed trees, oocytes from the left and right ovaries are not, suggesting a mixing of their progenitor pools. We also observed an increase in oocyte depth with mouse age, which can be explained either by depth-guided selection of oocytes for ovulation or by post-natal renewal. Overall, our study sheds light on substantial novel aspects of female germline preservation and development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.