ArticleChest2012
In vivo platelet activation in critically ill patients with primary 2009 influenza A(H1N1).
Article in Chest, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 77 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neutrophil Extracellular Trap Formation in Patients Undergoing Bone Marrow Transplant
Effect of SARS-CoV-2 Infection on Platelet Aggregation and Other Coagulation Parameters
Who cites it
77 citing papers in PubMed, 114 citations in OpenAlex.
- Targeting GPVI with glenzocimab in COVID-19 patients: Results from a randomized clinical trial.PloS one · 2024Trial
- Angiopoietin 2 Levels in the Risk Stratification and Mortality Outcome Prediction of Sepsis-Associated Coagulopathy.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Trial
- P-Selectin and Platelet-Monocyte Interaction in Inflammation: Mechanisms, Hypothesis, and Open Questions.Journal of inflammation research · 2026Review
- Review
- Attachment orientation and platelet activity.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- Differential platelet protein release profiles in community-acquired pneumonia and COVID-19.ERJ open research · 2025Article
- Infective or Non-Infective Endocarditis: A Brief Literature Review Based on a Case Report.Journal of clinical medicine · 2025Review
- Article
- Safety analysis of Oseltamivir and Baloxavir Marboxil after market approval: a pharmacovigilance study based on the FDA adverse event reporting system.BMC infectious diseases · 2024Article
- Plasma growth factors maintain constitutive translation in platelets to regulate reactivity and thrombotic potential.Blood advances · 2024Article
- The Role of the Complement System in the Pathogenesis of Infectious Forms of Hemolytic Uremic Syndrome.Biomolecules · 2023Review
- Alterations in the megakaryocyte transcriptome impacts platelet function in sepsis and COVID-19 infection.Thrombosis research · 2023Article
- Performance of Platelet Mass Index as a Marker of Severity for Sepsis and Septic Shock in Children.Journal of pediatric intensive care · 2023Article
- Evaluating Effects of AIV Infection Status on Ducks Using a Flow Cytometry-Based Differential Blood Count.Microbiology spectrum · 2023Article
- Blood Platelets in Infection: The Multiple Roles of the Platelet Signalling Machinery.International journal of molecular sciences · 2023Review
- Increased platelet activation and lower platelet-monocyte aggregates in COVID-19 patients with severe pneumonia.PloS one · 2023Article
- Understanding COVID-19-associated coagulopathy.Nature reviews. Immunology · 2022Review
- A review of pathophysiological mechanism, diagnosis, and treatment of thrombosis risk associated with COVID-19 infection.International journal of cardiology. Heart & vasculature · 2022Review
- Infection of lung megakaryocytes and platelets by SARS-CoV-2 anticipate fatal COVID-19.Cellular and molecular life sciences : CMLS · 2022Article
- Platelet-Released Factors: Their Role in Viral Disease and Applications for Extracellular Vesicle (EV) Therapy.International journal of molecular sciences · 2022Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundChanges in platelet reactivity during 2009 influenza A(H1N1) (A[H1N1]) have not been characterized.
methodsWe prospectively examined platelet activation and cytokine responses in patients with A(H1N1) (n = 20), matched patients with bacterial pneumonia (n = 15), and nonhospitalized, healthy control subjects (n = 10).
resultsPlatelet-monocyte aggregation was higher in patients with A(H1N1) (21.4% ± 4.7%) compared with patients with pneumonia (10.9% ± 3.7%) and control subjects (8.1% ± 4.5%, P < .05). Similarly, PAC-1 (antibody that binds to the active conformation of integrin α(IIb)β(3)) binding to platelets is increased in patients with A(H1N1) (9.5% ± 4.7%) compared with patients with pneumonia (1.0% ± 0.7%) and healthy subjects (0.61% ± 0.15%, P < .10). PAC-1 binding was twofold higher in patients with A(H1N1) with shock vs those without shock. IL-6 levels were elevated in patients with A(H1N1), indicating systemic inflammation consistent with activation of circulating platelets.
conclusionsThese findings, derived from a small but documented cohort of patients, demonstrate that platelet activation responses during A(H1N1) are enhanced-exceeding responses in patients with bacterial pneumonia-and provide new evidence that platelets may contribute to inflammatory responses during A(H1N1).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.