ArticleProceedings of the National Academy of Sciences of the United States of America2012
Identification of a cis-acting element that localizes mRNA to synapses.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 65 citations in OpenAlex.
- A comprehensive review on RNA subcellular localization prediction.Briefings in functional genomics · 2026Review
- Impact of PEGylation and hyaluronan functionalization on lipoplex-mediated mRNA delivery to the canine retina.Drug delivery · 2025Article
- MSlocPRED: deep transfer learning-based identification of multi-label mRNA subcellular localization.Briefings in bioinformatics · 2024Article
- The kpc-1 3'UTR facilitates dendritic transport and translation efficiency of mRNAs for dendrite arborization of a mechanosensory neuron important for male courtship.PLoS genetics · 2024Article
- Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding.Nature neuroscience · 2024Article
- Post-transcriptional regulation and subcellular localization of G-protein γ7 subunit: implications for striatal function and behavioral responses to cocaine.Frontiers in neuroanatomy · 2024Article
- The dynamic world of RNA: beyond translation to subcellular localization and function.Frontiers in genetics · 2024Article
- RNAlight: a machine learning model to identify nucleotide features determining RNA subcellular localization.Briefings in bioinformatics · 2023Article
- High-throughput identification of RNA localization elements in neuronal cells.Nucleic acids research · 2022Article
- Prediction of Synaptically Localized RNAs in Human Neurons Using Developmental Brain Gene Expression Data.Genes · 2022Article
- m6A and YTHDF proteins contribute to the localization of select neuronal mRNAs.Nucleic acids research · 2022Article
- Axonal mRNA localization and translation: local events with broad roles.Cellular and molecular life sciences : CMLS · 2021Review
- Intracellular mRNA transport and localized translation.Nature reviews. Molecular cell biology · 2021Review
- DM3Loc: multi-label mRNA subcellular localization prediction and analysis based on multi-head self-attention mechanism.Nucleic acids research · 2021Article
- RNA transport and local translation in neurodevelopmental and neurodegenerative disease.Nature neuroscience · 2021Review
- The Role of Alternative Polyadenylation in the Regulation of Subcellular RNA Localization.Frontiers in genetics · 2021Review
- Identification of 3' UTR motifs required for mRNA localization to myelin sheaths in vivo.PLoS biology · 2021Article
- Molecular mechanisms behind mRNA localization in axons.Open biology · 2020Review
- Mechanisms and consequences of subcellular RNA localization across diverse cell types.Traffic (Copenhagen, Denmark) · 2020Review
- Emerging Roles for 3' UTRs in Neurons.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Messenger RNA (mRNA) localization and regulated translation can spatially restrict gene expression to each of the thousands of synaptic compartments formed by a single neuron. Although cis-acting RNA elements have been shown to direct localization of mRNAs from the soma into neuronal processes, less is known about signals that target transcripts specifically to synapses. In Aplysia sensory-motor neuronal cultures, synapse formation rapidly redistributes the mRNA encoding the peptide neurotransmitter sensorin from neuritic shafts into synapses. We find that the export of sensorin mRNA from soma to neurite and the localization to synapse are controlled by distinct signals. The 3' UTR is sufficient for export into distal neurites, whereas the 5' UTR is required for concentration of reporter mRNA at synapses. We have identified a 66-nt element in the 5' UTR of sensorin that is necessary and sufficient for synaptic mRNA localization. Mutational and chemical probing analyses are consistent with a role for secondary structure in this process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.