ArticlePlant physiology2012
The U-Box/ARM E3 ligase PUB13 regulates cell death, defense, and flowering time in Arabidopsis.
Article in Plant physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed, 148 citations in OpenAlex.
- Armadillo repeat only gene VlARO confers resistance to Botrytis cinerea by promoting guaijaverin accumulation in grapevine.Plant cell reports · 2026Article
- Ubiquitin ligase HcPUB30 targets HcWRKY1 to regulate monoterpenoids synthesis in Hedychium coronarium.BMC plant biology · 2026Article
- Ubiquitin-Mediated Proteolysis as a Regulator of the Plant Defense-Growth Balance.Plants (Basel, Switzerland) · 2026Review
- Study on Genetic Transformation System of Cabbage (Plants (Basel, Switzerland) · 2025Article
- Phytophthora Avr3a-Like Effectors Target and Inhibit Cinnamyl Alcohol Dehydrogenase CAD5 to Suppress Plant Immunity.Molecular plant pathology · 2025Article
- Ancient allopolyploidy and specific subgenomic evolution drove the radiation of poplars and willows.Nature communications · 2025Article
- Dissecting the genetic architecture of key agronomic traits in lettuce using a MAGIC population.Genome biology · 2025Article
- TheFrontiers in plant science · 2025Article
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- The Vitis yeshanensis U-box E3 ubiquitin ligase VyPUB21 enhances resistance to powdery mildew by targeting degradation of NIM1-interacting (NIMIN) protein.Plant cell reports · 2024Article
- E3 Ubiquitin Ligase PUB23 in Kiwifruit Interacts with Trihelix Transcription Factor GT1 and Negatively Regulates Immune Responses againstInternational journal of molecular sciences · 2024Article
- Integrated proteomic analysis reveals interactions between phosphorylation and ubiquitination in rose response toHorticulture research · 2024Article
- Fine mapping of a Fusarium crown rot resistant locus on chromosome arm 6HL in barley by exploiting near isogenic lines, transcriptome profiling, and a large near isogenic line-derived population.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Article
- GIGANTEA regulatesPlant signaling & behavior · 2022Article
- How Many Faces Does the Plant U-Box E3 Ligase Have?International journal of molecular sciences · 2022Review
- Mapping of a novel clubroot disease resistance locus inFrontiers in plant science · 2022Article
- Quantitative trait locus mapping and improved resistance to sclerotinia stem rot in a backbone parent of rapeseed (Frontiers in plant science · 2022Article
- Tomato SlPUB24 enhances resistance to Xanthomonas euvesicatoria pv. perforans race T3.Horticulture research · 2021Article
- Interaction ofFrontiers in plant science · 2021Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The components in plant signal transduction pathways are intertwined and affect each other to coordinate plant growth, development, and defenses to stresses. The role of ubiquitination in connecting these pathways, particularly plant innate immunity and flowering, is largely unknown. Here, we report the dual roles for the Arabidopsis (Arabidopsis thaliana) Plant U-box protein13 (PUB13) in defense and flowering time control. In vitro ubiquitination assays indicated that PUB13 is an active E3 ubiquitin ligase and that the intact U-box domain is required for the E3 ligase activity. Disruption of the PUB13 gene by T-DNA insertion results in spontaneous cell death, the accumulation of hydrogen peroxide and salicylic acid (SA), and elevated resistance to biotrophic pathogens but increased susceptibility to necrotrophic pathogens. The cell death, hydrogen peroxide accumulation, and resistance to necrotrophic pathogens in pub13 are enhanced when plants are pretreated with high humidity. Importantly, pub13 also shows early flowering under middle- and long-day conditions, in which the expression of SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 and FLOWERING LOCUS T is induced while FLOWERING LOCUS C expression is suppressed. Finally, we found that two components involved in the SA-mediated signaling pathway, SID2 and PAD4, are required for the defense and flowering-time phenotypes caused by the loss of function of PUB13. Taken together, our data demonstrate that PUB13 acts as an important node connecting SA-dependent defense signaling and flowering time regulation in Arabidopsis.
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