ArticleJournal of applied physiology (Bethesda, Md. : 1985)2012
Airway responsiveness depends on the diffusion rate of methacholine across the airway wall.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Respiratory mechanics evaluation of mice submitted to intravenous methacholine: Bolus vs. continuous infusion.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- The role of iNKT cells on the phenotypes of allergic airways in a mouse model.Pulmonary pharmacology & therapeutics · 2017Article
- The gain of smooth muscle's contractile capacity induced by tone on in vivo airway responsiveness in mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Potential role of the airway wall in the asthma of obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Issues determining direct airways hyperresponsiveness in mice.Frontiers in physiology · 2012Article
- Airway Smooth Muscle Dynamics and Hyperresponsiveness: In and outside the Clinic.Journal of allergy · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
During methacholine challenge tests of airway responsiveness, it is invariably assumed that the administered dose of agonist is accurately reflected in the dose that eventually reaches the airway smooth muscle (ASM). However, agonist must traverse a variety of tissue obstacles to reach the ASM, during which the agonist is subjected to both enzymatic breakdown and removal by the bronchial and pulmonary circulations. This raises the possibility that a significant fraction of the deposited agonist may never actually make it to the ASM. To understand the nature of this effect, we measured the time course of changes in airway resistance elicited by various durations of methacholine aerosol in mice. We fit to these data a computational model of a dynamically contracting airway responding to agonist that diffuses through an airway compartment, thereby obtaining rate constants that reflect the diffusive barrier to methacholine. We found that these barriers can contribute significantly to the time course of airway narrowing, raising the important possibility that alterations in the diffusive barrier presented by the airway wall may play a role in pathologically altered airway responsiveness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.