ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2012
p38 MAPK regulates Bax activity and apoptosis in enterocytes at baseline and after intestinal resection.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
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- "Cytokine-Mediated tumor sensitization: mechanistic frameworks and therapeutic opportunities in cancer Immunotherapy".Clinical and experimental medicine · 2026Review
- Absent in melanoma 2 attenuates proliferation and migration and promotes apoptosis of human colorectal cancer cells by activating P38MAPK signaling pathway.Oncology research · 2023Article
- Molecular mechanism of Sishen pills in the treatment of diarrheal diabetic enteropathy based on network pharmacology.Medicine · 2022Article
- A novel maladaptive unfolded protein response as a mechanism for small bowel resection-induced liver injury.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- Lipid absorption and overall intestinal lymphatic transport are impaired following partial small bowel resection in mice.Scientific reports · 2022Article
- Recombinant platelet-derived growth factor-BB alleviates osteoarthritis in a rat model by decreasing chondrocyte apoptosis in vitro and in vivo.Journal of cellular and molecular medicine · 2021Article
- Liver injury after small bowel resection is prevented in obesity-resistant 129S1/SvImJ mice.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Inhibitory Effect of Bovine Adipose-Derived Mesenchymal Stem Cells on Lipopolysaccharide Induced Inflammation of Endometrial Epithelial Cells in Dairy Cows.Frontiers in veterinary science · 2021Article
- SOD1 suppresses pro-inflammatory immune responses by protecting against oxidative stress in colitis.Redox biology · 2020Article
- Effects of high-fat diet on liver injury after small bowel resection.Journal of pediatric surgery · 2020Article
- The Effect of Caffeic Acid on Spermatogonial Stem Cell-type A Cryopreservation.Reports of biochemistry & molecular biology · 2018Article
- SIRT7 depletion inhibits cell proliferation, migration, and increases drug sensitivity by activating p38MAPK in breast cancer cells.Journal of cellular physiology · 2018Article
- Both epidermal growth factor and insulin-like growth factor receptors are dispensable for structural intestinal adaptation.Journal of pediatric surgery · 2015Article
- Article
- Review article: the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases.Naunyn-Schmiedeberg's archives of pharmacology · 2014Review
- Insulin-like growth factor 2 and its enterocyte receptor are not required for adaptation in response to massive small bowel resection.Journal of pediatric surgery · 2014Article
- Si Shen Wan Inhibits mRNA Expression of Apoptosis-Related Molecules in p38 MAPK Signal Pathway in Mice with Colitis.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Adaptation: paradigm for the gut and an academic career.Journal of pediatric surgery · 2013Article
- Deletion of p38-alpha mitogen-activated protein kinase within the intestinal epithelium promotes colon tumorigenesis.Surgery · 2012Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Increased apoptosis in crypt enterocytes is a key feature of intestinal adaptation following massive small bowel resection (SBR). Expression of the proapoptotic factor Bax has been shown to be required for resection-induced apoptosis. It has also been demonstrated that p38-α MAPK (p38) is necessary for Bax activation and apoptosis in vitro. The present studies were designed to test the hypothesis that p38 is a key regulator of Bax activation during adaptation after SBR in vivo. Enterocyte expression of p38 was deleted by tamoxifen administration to activate villin-Cre in adult mice with a floxed Mapk14 (p38-α) gene. Proximal 50% SBR or sham operations were performed on wild-type (WT) and p38 intestinal knockout (p38-IKO) mice under isoflurane anesthesia. Mice were killed 3 or 7 days after operation, and adaptation was analyzed by measuring intestinal morphology, proliferation, and apoptosis. Bax activity was quantified by immunoprecipitation, followed by Western blotting. After SBR, p38-IKO mice had deeper crypts, longer villi, and accelerated proliferation compared with WT controls. Rates of crypt apoptosis were significantly lower in p38-IKO mice, both at baseline and after SBR. Levels of activated Bax were twofold higher in WT mice after SBR relative to sham. In contrast, activated Bax levels were reduced by 67% in mice after p38 MAPK deletion. Deleted p38 expression within the intestinal epithelium leads to enhanced adaptation and reduced levels of enterocyte apoptosis after massive intestinal resection. p38-regulated Bax activation appears to be an important mechanism underlying resection-induced apoptosis.
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