Trial reportAJNR. American journal of neuroradiology2012
Curative embolization of brain arteriovenous malformations with onyx: patient selection, embolization technique, and results.
Trial report in AJNR. American journal of neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- Treatment outcomes of Spetzler-Ponce grade A brain AVMs in a low-volume center: a systematic review and single institution experience.Neurosurgical review · 2025Pooled it
- Long-term complications and outcomes of therapeutic embolization of cerebral arteriovenous malformations: a systematic review.Sao Paulo medical journal = Revista paulista de medicina · 2024Pooled it
- Reporting of angiographic studies in patients diagnosed with a cerebral arteriovenous malformation: a systematic review.F1000Research · 2023Pooled it
- Prophylactic intra-arterial injection of lidocaine: a novel strategy to prevent endovascular embolization-induced trigeminocardiac reflex.Journal of neurointerventional surgery · 2023Trial
- Transvenous Embolisation-Based Strategies for Brain Arteriovenous Malformations: Systematic Review and Meta-Analysis.Biomedicines · 2026Review
- Review
- Anatomical and clinical factors associated with multiple-stage embolization of brain arteriovenous malformation as a stand alone treatment.Scientific reports · 2026Article
- Unexpected infectious complication following AVM embolization:eNeurologicalSci · 2026Review
- Recurrence of Cerebral Arteriovenous Malformation Following Complete Obliteration Through Endovascular Embolization.Translational stroke research · 2025Observational
- Paroxysmal sympathetic hyperactivity and cerebral salt wasting post management of arteriovenous malformation in a pediatric patient: A case report.Surgical neurology international · 2025Article
- Modified pressure cooker vs. push-and-plug technique in transarterial embolization for brain arteriovenous malformations: a retrospective comparative study.Frontiers in neurology · 2025Article
- The Microsurgical Resection of an Arteriovenous Malformation in a Patient with Thrombophilia: A Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2024Article
- Pediatric Cerebral Vascular Malformations : Current and Future Perspectives.Journal of Korean Neurosurgical Society · 2024Article
- Primary endovascular embolisation of intracranial arteriovenous malformations (AVM)-UK single centre experience.Neuroradiology · 2024Article
- Clinical and anatomic description of patients with arteriovenous malformation treated with endovascular therapy in a Mexican population.Journal of cerebrovascular and endovascular neurosurgery · 2023Article
- Application of the pressure cooker technique for transarterial embolization of brain arteriovenous malformations: Factors affecting obliteration and outcomes.Frontiers in neurology · 2023Article
- State of the Art in the Role of Endovascular Embolization in the Management of Brain Arteriovenous Malformations-A Systematic Review.Journal of clinical medicine · 2022Review
- Review
- Single-center experience with endovascular treatment of cerebral arteriovenous malformations with intent to cure in pediatric patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Prognostic factors for trigeminocardiac reflex during cerebrovascular intervention operation.Frontiers in surgery · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeA new curative embolization technique with Onyx for selected small and medium-sized superficially located brain AVMs was developed, which consists of obliteration of the nidus, including incremental occlusion of the draining veins. We report our first clinical results. MATERIALS AND
methodsBetween June 2008 and July 2011, 24 patients (7 women, 17 men; mean age, 41 years; range, 6-74 years) with AVMs were selected for curative embolization with Onyx. Presentation was hemorrhage in 14 and seizures in 10 patients. AVM location was frontal in 11, occipital in 6, parietal in 4, and temporal in 3. AVM size was a mean of 2.2 cm (median, 2; range, 1-3 cm).
resultsComplete angiographic obliteration of the AVM with Onyx in a single session was achieved in all 24 patients. There were no hemorrhagic or ischemic complications (0%; 95% CI, 0%-16.3%), and no new deficits induced by the treatment. Of 14 patients with ruptured AVMs, 1 patient who presented with a large frontal hematoma died shortly after surgical evacuation of the hematoma following complete embolization of a micro-AVM. Follow-up angiography at 3 months in 23 patients demonstrated a small AVM remnant in 1 that was treated with gamma knife radiosurgery. The other 22 AVMs remained completely occluded.
conclusionsIn selected patients with small and medium-sized superficial brain AVMs, as defined in our study, injection of Onyx by using a curative embolization technique in a single session seems to provide a safe and effective alternative to radiosurgery or surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.