ArticleCurrent treatment options in cardiovascular medicine2012
Update on the biology and treatment of lymphedema.
Article in Current treatment options in cardiovascular medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Animal Models of Lymphaticovenous Anastomosis: A Systematic Review of Current Evidence and Future Directions in Translational Research.Microsurgery · 2026Pooled it
- Trial
- Pilot studies demonstrate the potential benefits of antiinflammatory therapy in human lymphedema.JCI insight · 2018Trial
- Transient swelling versus lymphoedema in the first year following surgery for breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Trial
- Breast Cancer-related Lymphedema in Valle del Cauca, Colombia: Prevalence, Risk Factors, and Characterization.Plastic and reconstructive surgery. Global open · 2025Article
- Electroacupuncture Combined with Press Needles Alleviates Simple Obesity via VEGF-C/VEGFR-3/PI3K/AKT Signaling Pathway.Obesity facts · 2025Article
- A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Screening for breast cancer-related lymphoedema: self-assessment of symptoms and signs.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- Quality of life in adults with lymphedema cholestasis syndrome 1.Health and quality of life outcomes · 2018Article
- Burn Injury-Associated MHCIILymphatic research and biology · 2018Article
- Changes in arm tissue composition with slowly progressive weight-lifting among women with breast cancer-related lymphedema.Breast cancer research and treatment · 2017Article
- Local inhibition of elastase reduces EMILIN1 cleavage reactivating lymphatic vessel function in a mouse lymphoedema model.Clinical science (London, England : 1979) · 2016Article
- Blunted flow-mediated responses and diminished nitric oxide synthase expression in lymphatic thoracic ducts of a rat model of metabolic syndrome.American journal of physiology. Heart and circulatory physiology · 2016Article
- Colonic Insult Impairs Lymph Flow, Increases Cellular Content of the Lymph, Alters Local Lymphatic Microenvironment, and Leads to Sustained Inflammation in the Rat Ileum.Inflammatory bowel diseases · 2015Article
- Blockade of VEGF-C and VEGF-D modulates adipose tissue inflammation and improves metabolic parameters under high-fat diet.Molecular metabolism · 2015Article
- VEGFR-3 neutralization inhibits ovarian lymphangiogenesis, follicle maturation, and murine pregnancy.The American journal of pathology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
opinion statementThe past decade has produced an explosion of insights into lymphatic vascular development and structural biology and, in parallel, into the function of the lymphatics in health and in disease. In lymphedema, there is a spectrum that extends from primary (heritable) to acquired causes of disease. The diagnosis of lymphatic edema implicates a very specific treatment approach that is predicated upon the favorable impact of physiotherapy upon lymph flow and protein clearance from the edematous zones of the body. The recognition of the unique biology that accompanies lymphatic causes of edema has stimulated new research directions that are likely to translate into exciting new pharmacologic and molecular approaches to diagnosis and treatment.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.