ArticleClinical oral investigations2013
Influence of MMP-8 promoter polymorphism in early osseointegrated implant failure.
Article in Clinical oral investigations, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Association ofInternational journal of environmental research and public health · 2021Pooled it
- Aetiology of early implant failure: a scoping review.Clinical oral investigations · 2026Article
- Association of MMP-8 -799C/T Polymorphism with Peri-Implantitis: A Cross-Sectional Study.Journal of personalized medicine · 2025Article
- Matrix Metalloproteinases in Oral Health-Special Attention on MMP-8.Biomedicines · 2023Review
- The relationship between matrix metalloproteinases-8 andThe Saudi dental journal · 2023Review
- Peri-Implant Surgical Treatment Downregulates the Expression of sTREM-1 and MMP-8 in Patients with Peri-Implantitis: A Prospective Study.International journal of environmental research and public health · 2022Article
- The Role of Matrix Metalloproteinases (MMP-8, MMP-9, MMP-13) in Periodontal and Peri-Implant Pathological Processes.International journal of molecular sciences · 2022Review
- Association betweenPathogens (Basel, Switzerland) · 2021Review
- Expression of Interleukin-17, Tumor Necrosis Factor-Alpha, and Matrix Metalloproteinase-8 in Patients with Chronic Peri-Implant Mucositis.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- The Role of Matrix Metalloproteinases in Periodontal Disease.International journal of environmental research and public health · 2020Review
- Early implant failure: a retrospective analysis of contributing factors.Journal of periodontal & implant science · 2019Article
- The relationship between single nucleotide polymorphisms and dental implant loss: a scoping review.Clinical, cosmetic and investigational dentistry · 2019Article
- Current understanding of genetic polymorphisms as biomarkers for risk of biological complications in implantology.Journal of clinical and experimental dentistry · 2018Review
- Can Genetic Factors Compromise the Success of Dental Implants? A Systematic Review and Meta-Analysis.Genes · 2018Review
- Peri-Implant Sulcus Fluid (PISF) Matrix Metalloproteinase (MMP) -8 Levels in Peri-Implantitis.Journal of clinical and diagnostic research : JCDR · 2016Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDental implants consist in the treatment of choice to replace tooth loss. The knowledge that implant loss tends to cluster in subsets of individuals may indicate that host immuneinflammatory response is influenced by genetic factors. In fact, genetic polymorphisms influence the osseointegration process. The objective of this study was investigate the possible relationship between C-799T polymorphism in matrix metalloproteinase 8 (MMP-8) gene and early implant failure in nonsmoker patients. METHODS AND MATERIALS: Subjects were divided into two groups: control group (100 patients with one or more healthy implants) and test group (80 patients that had suffered one or more early implant failures). Genomic DNA from oral mucosa was amplified by PCR and analyzed by restriction endonucleases. The significance of the differences in observed frequencies of polymorphisms was assessed by Chi-square.
resultsStatistical analysis shows that in the MMP-8 gene, the T allele in 76.25% in the test group and the T/T genotype, 63.75% in the same group, may predispose to early loss of implants osseointegrated.
conclusionThese results suggest that polymorphism in the promoter region of MMP-8 gene is associated with early implant failure. This polymorphism can be a genetic marker to risk of implant loss. CLINICAL RELEVANCE: The determination of this genetic pattern in osseointegration would enable the identification of individuals at higher risk to loss implant. Thus, genetic markers will be identified, contributing to an appropriate preoperative selection and preparation of strategies for prevention and therapy individualized to modulate the genetic markers and increase the success rate of treatments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.