Evidence map›Paper›PMID 22382203›Full record

Trial reportEuropean journal of nutrition2013

Polyphenol-rich cranberry juice has a neutral effect on endothelial function but decreases the fraction of osteocalcin-expressing endothelial progenitor cells.

Andreas J Flammer, Elizabeth A Martin, Mario Gössl, R Jay Widmer, Ryan J Lennon, Jasmine A Sexton, Darrell Loeffler, Sundeep Khosla, Lilach O Lerman, Amir Lerman

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 9 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 9 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Andreas J FlammerDivision of Cardiovascular Diseases, Mayo Clinic and College of Medicine, 200 1st Street SW, Rochester, MN 55905, USA.
Elizabeth A Martin
Mario Gössl
R Jay Widmer
Ryan J Lennon
Jasmine A Sexton
Darrell Loeffler
Sundeep Khosla
Lilach O Lerman
Amir Lerman
Mayo Clinic · US

Funding

Tissue Oxygenation in Human Renovascular HypertensionP01HL085307 · NHLBI · MAYO CLINIC ROCHESTER · PI ROMERO, JUAN C · 2007 to 2011
$10.4M
Lp-PLA2 and Coronary Atherosclerosis in HumansR01HL092954 · NHLBI · MAYO CLINIC ROCHESTER · PI LERMAN, AMIR · 2009 to 2013
$2.1M
Role of Endothelial Progenitor Cells in vascular Aging and CalcificationR01AG031750 · NIA · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP, LERMAN, AMIR · 2010 to 2014
$2.0M
NHLBI NIH HHS 5R01HL92954-2NHLBI NIH HHS HL085307NHLBI NIH HHS P01 HL085307NHLBI NIH HHS R01 HL092954NIA NIH HHS 5R01AG31750-2NIA NIH HHS R01 AG031750
6 · The paper itself

Abstract

purposeCranberry juice (CJ) contains a remarkably high concentration of polyphenols, considered to be beneficial for cardiovascular and bone health. The current double-blind, randomized study was designed to test whether daily consumption of double-strength Ocean Spray light CJ (2 × 230 ml) over 4 months has beneficial effects on vascular function and on endothelial progenitor cells (EPCs) carrying the osteoblastic marker osteocalcin in particular.

methodsA total of 84 participants (49.5 ± 16.2 years) with peripheral endothelial dysfunction and cardiovascular risk factors were enrolled in this double-blind, randomized, controlled trial (69 completed the 4-month protocol-32 in the CJ group and 37 in the placebo group, respectively). Vascular responses to reactive hyperemia were measured non-invasively by peripheral arterial tonometry (EndoPAT). Peripheral blood mononuclear cells were stained for EPC markers, as well as osteocalcin, and counted by flow cytometry.

resultsBaseline characteristics were similar in both groups. The effect of CJ on peripheral endothelial function and on circulating EPC counts (CD34(+)/CD133(+)/KDR(+)) did not change during the study. A high percentage of EPCs expressed osteocalcin (59.4 ± 35.7%). CJ, as compared to placebo, induced a decrease in the fraction of EPCs expressing osteocalcin (-8.64 ± 48.98 and 19.13 ± 46.11%, respectively, p = 0.019). Systemic levels of the adhesion marker ICAM correlated significantly with the number of EPCs expressing osteocalcin.

conclusionsThe study demonstrated that long-term supplementation of polyphenol-rich CJ did not improve peripheral endothelial function. However, the decrease in the fraction of osteocalcin+ EPCs suggests a potential beneficial effect of polyphenol-rich CJ.

Indexed as

AdultAgedBeveragesBiomarkersCardiovascular DiseasesC-Reactive ProteinDouble-Blind MethodEndothelial CellsFemaleFlow CytometryHumansIntercellular Adhesion Molecule-1Interleukin-6Leukocytes, MononuclearLipoproteins, LDLMaleBiomarkersC-Reactive ProteinIntercellular Adhesion Molecule-1Interleukin-6Lipoproteins, LDLOsteocalcinoxidized low density lipoproteinPolyphenolsTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1

Identifiers

PMID22382203
PMCPMC3943114
OpenAlexW2086633696

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.