ArticleEnvironmental health perspectives2012
Low-level environmental cadmium exposure is associated with DNA hypomethylation in Argentinean women.
Article in Environmental health perspectives, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 129 citations in OpenAlex.
- High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genesClinical epigenetics · 2017Trial
- DNA methyl transferase (DNMT) gene polymorphisms could be a primary event in epigenetic susceptibility to schizophrenia.PloS one · 2014Trial
- Dietary and Environmental Exposure to Toxic Elements in Endometriosis: A Missing Piece of the Etiological Puzzle?Nutrients · 2026Review
- Integrated analysis of the blood metallome and DNA methylation, gene expression, and protein levels of immune-associated genes in residents from mining region.Environmental geochemistry and health · 2026Article
- Association between blood metal elements and lung cancer: a cross-sectional and Mendelian randomization study.Translational cancer research · 2025Article
- Exposure to Environmental Toxins & Autoimmune Conditions.Integrative medicine (Encinitas, Calif.) · 2024Review
- Global DNA methylation and the association between metal exposure and chronic kidney disease.Frontiers in public health · 2023Article
- Global DNA (LINE-1) methylation is associated with lead exposure and certain job tasks performed by electronic waste workers.International archives of occupational and environmental health · 2021Article
- In utero exposure to chlordecone affects histone modifications and activates LINE-1 in cord blood.Life science alliance · 2021Article
- Exposure to Environmental Toxins and Autoimmune Conditions.Integrative medicine (Encinitas, Calif.) · 2021Article
- Exposure to cadmium and copper triggers cytotoxic effects and epigenetic changes in human colorectal carcinoma HT-29 cells.Experimental and therapeutic medicine · 2021Article
- Hypomethylation of LINE-1 retrotransposons is associated with cadmium-induced testicular injury.Environmental science and pollution research international · 2020Article
- Implications for prenatal cadmium exposure and adverse health outcomes in adulthood.Toxicology and applied pharmacology · 2020Review
- Hypomethylation of LINE-1 repeat elements and global loss of DNA hydroxymethylation in vapers and smokers.Epigenetics · 2020Article
- Cadmium, Smoking, and Human Blood DNA Methylation Profiles in Adults from the Strong Heart Study.Environmental health perspectives · 2020Article
- DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status.Croatian medical journal · 2020Article
- Review
- Article
- Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression.Human molecular genetics · 2019Article
- Prenatal epigenetics diets play protective roles against environmental pollution.Clinical epigenetics · 2019Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCadmium, a common food pollutant, alters DNA methylation in vitro. Epigenetic effects might therefore partly explain cadmium's toxicity, including its carcinogenicity; however, human data on epigenetic effects are lacking.
objectiveWe evaluated the effects of dietary cadmium exposure on DNA methylation, considering other environmental exposures, genetic predisposition, and gene expression.
methodsConcentrations of cadmium, arsenic, selenium, and zinc in blood and urine of nonsmoking women (n = 202) from the northern Argentinean Andes were measured by inductively coupled mass spectrometry. Methylation in CpG islands of LINE-1 (long interspersed nuclear element-1; a proxy for global DNA methylation) and promoter regions of p16 [cyclin-dependent kinase inhibitor 2A (CDKN2A)] and MLH1 (mutL homolog 1) in peripheral blood were measured by bisulfite polymerase chain reaction pyrosequencing. Genotyping (n = 172) for the DNA (cytosine-5-)-methyltransferase 1 gene (DNMT1 rs10854076 and rs2228611) and DNA (cytosine-5-)-methyltransferase 3 beta gene (DNMT3B rs2424913 and rs2424932) was performed with Sequenom iPLEX GOLD SNP genotyping; and gene expression (n = 90), with DirectHyb HumanHT-12 (version 3.0).
resultsCadmium exposure was low: median concentrations in blood and urine were 0.36 and 0.23 µg/L, respectively. Urinary cadmium (natural log transformed) was inversely associated with LINE-1 methylation (β = -0.50, p = 0.0070; β = -0.44, p = 0.026, adjusted for age and coca chewing) but not with p16 or MLH1 methylation. Both DNMT1 rs10854076 and DNMT1 rs2228611 polymorphisms modified associations between urinary cadmium and LINE-1 (p-values for interaction in adjusted models were 0.045 and 0.064, respectively). The rare genotypes demonstrated stronger hypomethylation with increasing urinary cadmium concentrations. Cadmium was inversely associated with DNMT3B (r(S) = -0.28, p = 0.0086) but not with DNMT1 expression (r(S) = -0.075, p = 0.48).
conclusionEnvironmental cadmium exposure was associated with DNA hypomethylation in peripheral blood, and DNMT1 genotypes modified this association. The role of epigenetic modifications in cadmium-associated diseases needs clarification.
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