ArticleInternational journal of radiation oncology, biology, physics2012
Exposure to ionizing radiation causes long-term increase in serum estradiol and activation of PI3K-Akt signaling pathway in mouse mammary gland.
Article in International journal of radiation oncology, biology, physics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Interplay of IGF1R and estrogen signaling regulates hematopoietic stem and progenitor cells.bioRxiv : the preprint server for biology · 2024Article
- High-LET-Radiation-Induced Persistent DNA Damage Response Signaling and Gastrointestinal Cancer Development.Current oncology (Toronto, Ont.) · 2023Review
- Article
- Molecular and cellular basis of the dose-rate-dependent adverse effects of radiation exposure in animal models. Part I: Mammary gland and digestive tract.Journal of radiation research · 2023Review
- Longitudinal metabolic alterations in plasma of rats exposed to low doses of high linear energy transfer radiation.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2021Article
- Sensitizing endometrial cancer to ionizing radiation by multi-tyrosine kinase inhibition.Journal of gynecologic oncology · 2020Article
- Protons Show Greater Relative Biological Effectiveness for Mammary Tumorigenesis with Higher ERα- and HER2-Positive Tumors Relative to γ-rays in APCInternational journal of radiation oncology, biology, physics · 2020Article
- Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and interaction with hormonal regulation of the breast.Archives of toxicology · 2020Review
- Analysis of genes involved in the PI3K/Akt pathway in radiation- and MNU-induced rat mammary carcinomas.Journal of radiation research · 2017Article
- Space radiation exposure persistently increased leptin and IGF1 in serum and activated leptin-IGF1 signaling axis in mouse intestine.Scientific reports · 2016Article
- Radiation persistently promoted oxidative stress, activated mTOR via PI3K/Akt, and downregulated autophagy pathway in mouse intestine.The international journal of biochemistry & cell biology · 2014Article
- Long-term differential changes in mouse intestinal metabolomics after γ and heavy ion radiation exposure.PloS one · 2014Article
- Pharmacologic profiling of phosphoinositide 3-kinase inhibitors as mitigators of ionizing radiation-induced cell death.The Journal of pharmacology and experimental therapeutics · 2013Article
- Caloric restriction augments radiation efficacy in breast cancer.Cell cycle (Georgetown, Tex.) · 2013Article
- Temporal mTOR inhibition protects Fbxw7-deficient mice from radiation-induced tumor development.Aging · 2013Article
- Article
- Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland.Radiation oncology (London, England) · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeExposure to ionizing radiation is an established risk factor for breast cancer. Radiation exposure during infancy, childhood, and adolescence confers the highest risk. Although radiation is a proven mammary carcinogen, it remains unclear where it acts in the complex multistage process of breast cancer development. In this study, we investigated the long-term pathophysiologic effects of ionizing radiation at a dose (2 Gy) relevant to fractionated radiotherapy. METHODS AND MATERIALS: Adolescent (6-8 weeks old; n = 10) female C57BL/6J mice were exposed to 2 Gy total body γ-radiation, the mammary glands were surgically removed, and serum and urine samples were collected 2 and 12 months after exposure. Molecular pathways involving estrogen receptor-α (ERα) and phosphatidylinositol-3-OH kinase (PI3K)-Akt signaling were investigated by immunohistochemistry and Western blot.
resultsSerum estrogen and urinary levels of the oncogenic estrogen metabolite (16αOHE1) were significantly increased in irradiated animals. Immunostaining for the cellular proliferative marker Ki-67 and cyclin-D1 showed increased nuclear accumulation in sections of mammary glands from irradiated vs. control mice. Marked increase in p85α, a regulatory sub-unit of the PI3K was associated with increase in Akt, phospho-Akt, phospho-BAD, phospho-mTOR, and c-Myc in irradiated samples. Persistent increase in nuclear ERα in mammary tissues 2 and 12 months after radiation exposure was also observed.
conclusionsTaken together, our data not only support epidemiologic observations associating radiation and breast cancer but also, specify molecular events that could be involved in radiation-induced breast cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.