ArticleJournal of biomechanics2012
Mechanical property changes during neonatal development and healing using a multiple regression model.
Article in Journal of biomechanics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- Neonatal Achilles Tendon Microstructure is Negatively Impacted by Decorin and Biglycan Knockdown After Injury and During Development.Annals of biomedical engineering · 2024Article
- Preclinical tendon and ligament models: Beyond the 3Rs (replacement, reduction, and refinement) to 5W1H (why, who, what, where, when, how).Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Review
- Tendon Extracellular Matrix Assembly, Maintenance and Dysregulation Throughout Life.Advances in experimental medicine and biology · 2021Review
- Models of tendon development and injury.BMC biomedical engineering · 2019Article
- Dynamic Loading and Tendon Healing Affect Multiscale Tendon Properties and ECM Stress Transmission.Scientific reports · 2018Article
- Multiscale Poroviscoelastic Compressive Properties of Mouse Supraspinatus Tendons Are Altered in Young and Aged Mice.Journal of biomechanical engineering · 2018Article
- Injury response of geriatric mouse patellar tendons.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Multiscale regression modeling in mouse supraspinatus tendons reveals that dynamic processes act as mediators in structure-function relationships.Journal of biomechanics · 2016Article
- Improved biomechanical and biological outcomes in the MRL/MpJ murine strain following a full-length patellar tendon injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Article
- Micromechanical poroelastic finite element and shear-lag models of tendon predict large strain dependent Poisson's ratios and fluid expulsion under tensile loading.Acta biomaterialia · 2015Article
- The tendon injury response is influenced by decorin and biglycan.Annals of biomedical engineering · 2014Article
- Article
- Determining the contribution of glycosaminoglycans to tendon mechanical properties with a modified shear-lag model.Journal of biomechanics · 2013Article
- Mechanical, compositional, and structural properties of the mouse patellar tendon with changes in biglycan gene expression.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2013Article
- The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly.The FEBS journal · 2013Review
- Structure-function relationships of postnatal tendon development: a parallel to healing.Matrix biology : journal of the International Society for Matrix Biology · 2013Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
During neonatal development, tendons undergo a well orchestrated process whereby extensive structural and compositional changes occur in synchrony to produce a normal tissue. Conversely, during the repair response to injury, structural and compositional changes occur, but a mechanically inferior tendon is produced. As a result, developmental processes have been postulated as a potential paradigm for elucidation of mechanistic insight required to develop treatment modalities to improve adult tissue healing. The objective of this study was to compare and contrast normal development with injury during early and late developmental healing. Using backwards multiple linear regressions, quantitative and objective information was obtained into the structure-function relationships in tendon. Specifically, proteoglycans were shown to be significant predictors of modulus during early developmental healing but not during late developmental healing or normal development. Multiple independent parameters predicted percent relaxation during normal development, however, only biglycan and fibril diameter parameters predicted percent relaxation during early developmental healing. Lastly, multiple differential predictors were observed between early development and early developmental healing; however, no differential predictors were observed between late development and late developmental healing. This study presents a model through which objective analysis of how compositional and structural parameters that affect the development of mechanical parameters can be quantitatively measured. In addition, information from this study can be used to develop new treatment and therapies through which improved adult tendon healing can be obtained.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.