ArticleBMJ (Clinical research ed.)2012
Cardiovascular disease in kidney donors: matched cohort study.
Article in BMJ (Clinical research ed.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07431515 (The Long-term Risk of Cardiovascular Disease and Mortality in Living Kidney Donors), which is not on this map. Cited by 76 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Long-term Risk of Cardiovascular Disease and Mortality in Living Kidney Donors
Who cites it
76 citing papers in PubMed, 5 syntheses or guidelines pooled it, 200 citations in OpenAlex.
- Pregnancy after living kidney donation, a systematic review of the available evidence, and a review of the current guidance.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Pooled it
- Long-term mortality of living kidney donors: a systematic review and meta-analysis.International urology and nephrology · 2021Pooled it
- KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors.Transplantation · 2017Guideline
- Kidney-Failure Risk Projection for the Living Kidney-Donor Candidate.The New England journal of medicine · 2016Pooled it
- Prevention of chronic kidney disease and subsequent effect on mortality: a systematic review and meta-analysis.PloS one · 2013Pooled it
- Destination Transplant: Protocol for a Parallel-group Randomized Trial of an Educational Intervention to Increase Kidney Transplant Among Black People on the Transplant Waiting List.Transplantation direct · 2021Trial
- Effect of A Reduction in glomerular filtration rate after NEphrectomy on arterial STiffness and central hemodynamics: rationale and design of the EARNEST study.American heart journal · 2014Trial
- Donor medicine: An emerging field in nephrology.World journal of nephrology · 2026Review
- Recommendations for Living Kidney Donor Follow-Up in Canada.Clinical transplantation · 2026Article
- Risk of Inguinal Hernia Repair Following Laparoscopic Living Donor Nephrectomy: A Population-Based Cohort Study.Canadian journal of kidney health and disease · 2026Article
- Long-Term Risk for Scrotal Hydrocelectomy After Laparoscopic Living Donor Nephrectomy: A Population-Based Matched Cohort Study.Canadian journal of kidney health and disease · 2026Article
- Long-Term Outcomes Across Age and Risk Profiles in a Caucasian Living Kidney Donor Cohort.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Long-Term Outcomes of Living Kidney Donors in a Developing Country: A Single-Center Study.Journal of clinical medicine · 2025Article
- Estimating the Contribution of Renal Function to Endothelial Dysfunction and Subclinical Inflammation with a Two-Cohort Study: Living Kidney Donors and Their Transplant Recipients.International journal of molecular sciences · 2025Observational
- Outcomes of Living Kidney Donors Following Donor Nephrectomy in Aotearoa New Zealand.Kidney international reports · 2025Article
- Pros and cons of live kidney donation in prediabetics: A critical review and way forward.World journal of transplantation · 2024Review
- Long-term Medical Outcomes of Living Kidney Donors.Mayo Clinic proceedings · 2022Review
- Increased risk of ischaemic heart disease after kidney donation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- Risk for subsequent hypertension and cardiovascular disease after living kidney donation: is it clinically relevant?Clinical kidney journal · 2022Review
- Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors at 10 institutions in 3 countries.
Funding
Abstract
objectiveTo determine whether people who donate a kidney have an increased risk of cardiovascular disease.
designRetrospective population based matched cohort study.
participantsAll people who were carefully selected to become a living kidney donor in the province of Ontario, Canada, between 1992 and 2009. The information in donor charts was manually reviewed and linked to provincial healthcare databases. Matched non-donors were selected from the healthiest segment of the general population. A total of 2028 donors and 20,280 matched non-donors were followed for a median of 6.5 years (maximum 17.7 years). Median age was 43 at the time of donation (interquartile range 34-50) and 50 at the time of follow-up (42-58).
main outcome measuresThe primary outcome was a composite of time to death or first major cardiovascular event. The secondary outcome was time to first major cardiovascular event censored for death.
resultsThe risk of the primary outcome of death and major cardiovascular events was lower in donors than in non-donors (2.8 v 4.1 events per 1000 person years; hazard ratio 0.66, 95% confidence interval 0.48 to 0.90). The risk of major cardiovascular events censored for death was no different in donors than in non-donors (1.7 v 2.0 events per 1000 person years; 0.85, 0.57 to 1.27). Results were similar in all sensitivity analyses. Older age and lower income were associated with a higher risk of death and major cardiovascular events in both donors and non-donors when each group was analysed separately.
conclusionsThe risk of major cardiovascular events in donors is no higher in the first decade after kidney donation compared with a similarly healthy segment of the general population. While we will continue to follow people in this study, these interim results add to the evidence base supporting the safety of the practice among carefully selected donors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.