ReviewThe Veterinary clinics of North America. Small animal practice2012
Toxicology of avermectins and milbemycins (macrocylic lactones) and the role of P-glycoprotein in dogs and cats.
Review in The Veterinary clinics of North America. Small animal practice, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 125 citations in OpenAlex.
- Scientific Opinion on waiving of the dog studies in the regulatory process of agrochemicals approval.EFSA journal. European Food Safety Authority · 2026Article
- Effects of ivermectin on the activation and desensitization of the human GABAMolecular pharmacology · 2026Article
- Iatrogenic doramectin poisoning in newborn beef calves.Veterinary research communications · 2026Article
- Field evaluation of a topical combination of ivermectin, imidacloprid, and praziquantel for flea control in cats under routine clinical.Frontiers in parasitology · 2026Article
- Comparison of adsorptive capacity for different types of activated charcoal for common veterinary toxicants.Frontiers in veterinary science · 2026Article
- Safety of Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) in homozygous MDR1-mutant collie dogs.Parasites & vectors · 2025Article
- Safety of Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) in dogs infected with adult heartworms (Dirofilaria immitis).Parasites & vectors · 2025Article
- Design, Optimization, Manufacture and Characterization of Milbemycin Oxime Nanoemulsions.Pharmaceutics · 2025Article
- Antemortem diagnostic tests and treatment outcomes using ivermectin in 13 cases of presumptive feline neurocuterebriasis.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- High-Throughput Empirical and Virtual Screening to Discover Novel Inhibitors of Polyploid Giant Cancer Cells in Breast Cancer.bioRxiv : the preprint server for biology · 2024Article
- Reprogramming tumor immune microenvironment by milbemycin oxime results in pancreatic tumor growth suppression and enhanced anti-PD-1 efficacy.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Penetration Enhancer-Free Mixed Micelles for Improving Eprinomectin Transdermal c Efficiency in Animal Parasitic Infections Therapy.International journal of nanomedicine · 2024Article
- A review of moxidectin vs. other macrocyclic lactones for prevention of heartworm disease in dogs with an appraisal of two commercial formulations.Frontiers in veterinary science · 2024Review
- Effect of fluralaner on the biology, survival, and reproductive fitness of the neotropical malaria vector Anopheles aquasalis.Malaria journal · 2023Article
- Canine Systemic Insecticides Fluralaner and Lotilaner Induce Acute Mortality of Triatoma gerstaeckeri, North American Vector of the Chagas Disease Parasite.The American journal of tropical medicine and hygiene · 2023Article
- Assembly of a Draft Genome for the Mouse EctoparasiteJournal of the American Association for Laboratory Animal Science : JAALAS · 2023Article
- Safety of oral afoxolaner formulated with or without milbemycin oxime in homozygous MDR1-deficient collie dogs.Journal of veterinary pharmacology and therapeutics · 2022Article
- Assessment of Avermectins-Induced Toxicity in Animals.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Effects of Avermectins on the Environment Based on Its Toxicity to Plants and Soil Invertebrates-a Review.Water, air, and soil pollution · 2022Review
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The macrocyclic lactones (MLs) are parasiticides able to kill a wide variety of arthropods and nematodes. They have a high margin of safety for labeled indications, and ivermectin has become the best-selling antiparasitic in the world. Dogs of certain breeds and mixtures of those breeds have a defect in the ABCB1 gene (formerly MDR1 gene) that results in a lack of functional P-glycoprotein, which leads to accumulation of the MLs in the central nervous system and a higher risk of adverse effects when exposed. There is no specific antidote for ML toxicosis so the most important part of treatment is good supportive care.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.