ArticleOrganic and medicinal chemistry letters2012
Four butyrolactones and diverse bioactive secondary metabolites from terrestrial Aspergillus flavipes MM2: isolation and structure determination.
Article in Organic and medicinal chemistry letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Structurally diverse polyketides and alkaloids produced by a plant-derived fungus Penicillium canescens L1.Natural products and bioprospecting · 2025Article
- New Polyketides from a Marine Sponge-Derived Fungus,Marine drugs · 2025Article
- Recent Progress on Natural α-Glucosidase Inhibitors Derived from the Plants and Microorganisms.Current medicinal chemistry · 2025Review
- Bio-fabricated zinc oxide nanoparticles mediated by endophytic fungusFrontiers in microbiology · 2024Article
- Comparative genomic and metabolomic study of three Streptomyces sp. differing in biological activity.MicrobiologyOpen · 2023Article
- Chemical Constituents of the Deep-Sea-DerivedMarine drugs · 2022Article
- Identification of Antibacterial Metabolites from Endophytic FungusMolecules (Basel, Switzerland) · 2022Article
- Terrien, a metabolite made byPeerJ · 2022Article
- Application of Principal Component Analysis (PCA) to the Evaluation and Screening of Multiactivity Fungi.Journal of Ocean University of China : JOUC · 2022Article
- Soybean-associated endophytic fungi as potential source for anti-COVID-19 metabolites supported by docking analysis.Journal of applied microbiology · 2021Article
- Production of Terretonin N and Butyrolactone I by ThermophilicMolecules (Basel, Switzerland) · 2021Article
- Aspulvinones Suppress Postprandial Hyperglycemia as Potent α-Glucosidase Inhibitors FromFrontiers in chemistry · 2021Article
- Coumamarin: a first coumarinyl calcium complex isolated from nature.The Journal of antibiotics · 2019Article
- Chemical Constituents of the Marine-Derived FungusMarine drugs · 2018Article
- Terretonin N: A New Meroterpenoid from Nocardiopsis sp.Molecules (Basel, Switzerland) · 2018Article
- Article
- Mass Spectrometric Characteristics of Prenylated Indole Derivatives from Marine-Derived Penicillium sp. NH-SL.Marine drugs · 2017Article
- Bioactive compounds of Aspergillus terreus-F7, an endophytic fungus from Hyptis suaveolens (L.) Poit.World journal of microbiology & biotechnology · 2017Article
- Phytotoxic, Antifungal and Immunosuppressive Metabolites from Aspergillus terreus QT122 Isolated from the Gut of Dragonfly.Current microbiology · 2017Article
- Production of hydroxy marilone C as a bioactive compound fromJournal, genetic engineering & biotechnology · 2016Article
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Authors and funding
5 authors.
Funding
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Abstract
The chemical constituents and biological activities of the terrestrial Aspergillus flavipes MM2 isolated from Egyptian rice hulls are reported. Seven bioactive compounds were obtained, of which one sterol: ergosterol (1), four butyrolactones: butyrolactone I (2), aspulvinone H (3), butyrolactone-V (6) and 4,4'-diydroxypulvinone (7), along with 6-methylsalicylic acid (4) and the cyclopentenone analogue; terrien (5). Structures of the isolated compounds were deduced by intensive studies of their 1D & 2D NMR, MS data and comparison with related structures. The strain extract and the isolated compounds (1-7) were biologically studied against number of microbial strains, and brine shrimp for cytotoxicity. In this article, the taxonomical characterization of A. flavipes MM2 along with its upscale fermentation, isolation and structural assignment of the obtained bioactive metabolites, and evaluate their antimicrobial and cytotoxic activities were described.
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