ArticleCurrent neuropharmacology2011
Raphe-Hippocampal Serotonin Neurotransmission In The Sex Related Differences of Adaptation to Stress: Focus on Serotonin-1A Receptor.
Article in Current neuropharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 44 citations in OpenAlex.
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- Sex-dependent impact of parental verbal abuse on brain lateralization of language.Neurobiology of stress · 2025Article
- Serotonin Signaling in Hippocampus during Initial Cocaine Abstinence Drives Persistent Drug Seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Elevated Plasma Tryptophan in Patients with Anorexia Nervosa Compared with Hypotrophic Controls.JMA journal · 2024Article
- The mutually reinforcing dynamics between pain and stress: mechanisms, impacts and management strategies.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- Large-scale network dynamics in neural response to emotionally negative stimuli linked to serotonin 1A binding in major depressive disorder.Molecular psychiatry · 2021Article
- Targeting Serotonin1A Receptors for Treating Chronic Pain and Depression.Current neuropharmacology · 2019Review
- Role of Estradiol in the Expression of Genes Involved in Serotonin Neurotransmission: Implications for Female Depression.Current neuropharmacology · 2019Review
- Fasting leptin and glucose in normal weight, over weight and obese men and women diabetes patients with and without clinical depression.Metabolic brain disease · 2017Article
- Are epigenetic changes in the intrauterine environment related to newborn neurobehavior?Epigenomics · 2014Article
- Prediction of selective serotonin reuptake inhibitor response using diffusion-weighted MRI.Frontiers in psychiatry · 2013Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
Stress is the major predisposing and precipitating factor in the onset of depression which is the most significant mental health risk for women. Behavioral studies in animal models show that female sex though less affected by an acute stressor; exposure to repeated stressors induces coping deficits to impair adaptation in them. A decrease in the function of 5-hydroxytryptamine (5-HT; serotonin) in the hippocampus and an increased function of the 5-HT-1A receptor in the raphe nucleus coexist in depression. Pharmacological and neurochemical data are relevant that facilitation of serotonin neurotransmission via hippocampus due to desensitization of somatodendritic 5-HT1A receptors may lead to adaptation to stress. The present article reviews research on sex related differences of raphe-hippocampal serotonin neurotransmission to find a possible answer that may account for the sex differences of adaptation to stress reported in preclinical research and greater incidence of depression in women than men.
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