ArticlePaediatrics & child health2011
Premedication for endotracheal intubation in the newborn infant.
Article in Paediatrics & child health, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04409665 (The Use of Sedation Drugs in the Procedure of Administering Surfactant Without Intubation), which is not on this map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Use of Sedation Drugs in the Procedure of Administering Surfactant Without Intubation (LISA/MIST): a Randomized Study Comparing Intravenous Ketamine With Sublingual 30% Glucose
Who cites it
27 citing papers in PubMed, 86 citations in OpenAlex.
- Trial
- Randomized trial of laryngeal mask airway versus endotracheal intubation for surfactant delivery.Journal of perinatology : official journal of the California Perinatal Association · 2016Trial
- Association of atropine use during neonatal intubation with cardiac arrest, severe bradycardia, and other adverse events: a report from NEAR4NEOS.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Remifentanil and Neonatal Intubation: Balancing Efficacy and Safety.Children (Basel, Switzerland) · 2026Review
- Improving LISA Practice: An Ongoing Observational Quality Improvement Initiative Following Initiation of Less-Invasive Surfactant Administration in a Level IV NICU.Children (Basel, Switzerland) · 2026Article
- Complete atrioventricular block during neonatal intubation: a case report.Resuscitation plus · 2025Article
- Continuous improvement of non-emergent neonatal intubations in a level IV NICU.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Less invasive surfactant administration methods: Who, what and how.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Pre-Medications for Non-Emergency Tracheal Intubation in the United States Neonatal Intensive Care Units.Cureus · 2024Article
- Less Invasive Surfactant Administration: A Viewpoint.American journal of perinatology · 2024Review
- Sedation Prior to Intubation at Birth in Infants with Congenital Diaphragmatic Hernia: An International Survey on Current Practices.Neonatology · 2023Article
- Standardizing premedication for non-emergent neonatal tracheal intubations improves compliance and patient outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Premedication before laryngoscopy in neonates: Evidence-based statement from the French society of neonatology (SFN).Frontiers in pediatrics · 2022Review
- Alternative Methods of Surfactant Administration in Preterm Infants with Respiratory Distress Syndrome: State of the Art.Turkish archives of pediatrics · 2021Article
- New techniques, new challenges-The dilemma of pain management for less invasive surfactant administration?Paediatric & neonatal pain · 2021Review
- Propofol versus placebo (with rescue with ketamine) before less invasive surfactant administration: study protocol for a multicenter, double-blind, placebo controlled trial (PROLISA).BMC pediatrics · 2020Article
- Premedication with neuromuscular blockade and sedation during neonatal intubation is associated with fewer adverse events.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Premedication practices for delivery room intubations in premature infants in France: Results from the EPIPAGE 2 cohort study.PloS one · 2019Article
- Cerebral Oxygenation During Neonatal Intubation-Ancillary Study of the Prettineo-Study.Frontiers in pediatrics · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endotracheal intubation, a common procedure in newborn care, is associated with pain and cardiorespiratory instability. The use of premedication reduces the adverse physiological responses of bradycardia, systemic hypertension, intracranial hypertension and hypoxia. Perhaps more importantly, premedication decreases the pain and discomfort associated with the procedure. All newborn infants, therefore, should receive analgesic premedication for endotracheal intubation except in emergency situations. Based on current evidence, an optimal protocol for premedication is to administer a vagolytic (intravenous [IV] atropine 20 μg/kg), a rapid-acting analgesic (IV fentanyl 3 μg/kg to 5 μg/kg; slow infusion) and a short-duration muscle relaxant (IV succinylcholine 2 mg/kg). Intubations should be performed or supervised by trained staff, with close monitoring of the infant throughout.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.