Evidence map›Paper›PMID 22379110›Full record

ArticleCirculation2012

Incidence and prognosis of resistant hypertension in hypertensive patients.

Stacie L Daugherty, J David Powers, David J Magid, Heather M Tavel, Frederick A Masoudi, Karen L Margolis, Patrick J O'Connor, Joe V Selby, P Michael Ho

2 registry-linked trialsOpen access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 366 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
366citing papers in PubMed, 9 pooled it
58.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01689415 terminatednot on this map

Pilot Study in Renal Denervation in Patients With Stroke and Uncontrolled Hypertension

TypeobservationalSponsorBispebjerg HospitalRan2012 to 2014Enrolled25ConditionsStroke, Hypertension
NCT03753633 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Efficiency of Speech Therapy in Resistant Hypertensive Patients With Mild Obstructive Sleep Apnea Syndrome

TypeinterventionalSponsorUniversidade Federal do Rio de JaneiroRan2017 to 2019Enrolled50ConditionsSleep Apnea, Obstructive, Hypertension SecondaryArmsSpeech therapy, Control
3 · Its place in the literature

Who cites it

366 citing papers in PubMed, 9 syntheses or guidelines pooled it, 906 citations in OpenAlex.

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306 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Stacie L DaughertyDivision of Cardiology, University of Colorado-Denver, 12605 E 16th Ave., Aurora, CO 80045, USA. stacie.daugherty@ucdenver.edu
J David Powers
David J Magid
Heather M Tavel
Frederick A Masoudi
Karen L Margolis
Patrick J O'Connor
Joe V Selby
P Michael Ho
Patient-Centered Outcomes Research Institute · USDenver Health Medical Center · USHealthPartners · USKaiser Permanente · USUniversity of Colorado Denver · US

Funding

HMO Research Network Cardiovascular Research NetworkU19HL091179 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI GO, ALAN S · 2007 to 2011
$8.7M
Gender Disparities in Invasive CVD Procedure Use: the Role of Provider BiasK08HL103776 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI DAUGHERTY, STACIE LUTHER · 2010 to 2014
$657k
NHLBI NIH HHS K08 HL103776NHLBI NIH HHS K08HL103776NHLBI NIH HHS U19 HL091179NHLBI NIH HHS U19HL91179-01
6 · The paper itself

Abstract

backgroundDespite a recent American Heart Association (AHA) consensus statement emphasizing the importance of resistant hypertension, the incidence and prognosis of this condition are largely unknown. METHODS AND

resultsThis retrospective cohort study in 2 integrated health plans included patients with incident hypertension in whom treatment was begun between 2002 and 2006. Patients were followed up for the development of resistant hypertension based on AHA criteria of uncontrolled blood pressure despite use of ≥3 antihypertensive medications, with data collected on prescription filling information and blood pressure measurement. We determined incident cardiovascular events (death or incident myocardial infarction, heart failure, stroke, or chronic kidney disease) in patients with and without resistant hypertension with adjustment for patient and clinical characteristics. Among 205 750 patients with incident hypertension, 1.9% developed resistant hypertension within a median of 1.5 years from initial treatment (0.7 cases per 100 person-years of follow-up). These patients were more often men, were older, and had higher rates of diabetes mellitus than nonresistant patients. Over 3.8 years of median follow-up, cardiovascular event rates were significantly higher in those with resistant hypertension (unadjusted 18.0% versus 13.5%, P<0.001). After adjustment for patient and clinical characteristics, resistant hypertension was associated with a higher risk of cardiovascular events (hazard ratio, 1.47; 95% confidence interval, 1.33-1.62).

conclusionsAmong patients with incident hypertension in whom treatment was begun, 1 in 50 patients developed resistant hypertension. Patients with resistant hypertension had an increased risk of cardiovascular events, which supports the need for greater efforts toward improving hypertension outcomes in this population.

Indexed as

Cohort StudiesFemaleFollow-Up StudiesHumansHypertensionIncidenceMaleMiddle AgedPrognosisRetrospective Studies

Identifiers

PMID22379110
PMCPMC3343635
OpenAlexW2089259727

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.