ArticleScience translational medicine2012
CD4+ T cells and HIV: A paradoxical Pas de Deux.
Article in Science translational medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Fitness Cost of Antiretroviral Drug Resistance Mutations on thePathogens (Basel, Switzerland) · 2021Article
- Mitochondrial and Oxidative Impacts of Short and Long-term Administration of HAART on HIV Patients.Current clinical pharmacology · 2020Article
- Article
- Factors Associated with the Size of HIV DNA Reservoir.Chinese medical journal · 2017Review
- Mucosal Regulatory T Cells and T Helper 17 Cells in HIV-Associated Immune Activation.Frontiers in immunology · 2016Article
- Second European Round Table on the Future Management of HIV: 10-11 October 2014, Barcelona, Spain.Journal of virus eradication · 2015Article
- CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells.PLoS pathogens · 2014Article
- Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals.PLoS pathogens · 2014Article
- Increased stability and limited proliferation of CD4+ central memory T cells differentiate nonprogressive simian immunodeficiency virus (SIV) infection of sooty mangabeys from progressive SIV infection of rhesus macaques.Journal of virology · 2014Article
- Host-pathogen interaction in HIV infection.Current opinion in immunology · 2013Review
- Immune activation and HIV persistence: implications for curative approaches to HIV infection.Immunological reviews · 2013Review
- Mucosal immunology of HIV infection.Immunological reviews · 2013Review
- Microbial translocation, immune activation, and HIV disease.Trends in microbiology · 2013Review
- HIV-1 and the immune response to TB.Future virology · 2013Article
- Article
- Article
Corrections and comments
- Comment on
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When it comes to HIV infection, CD4(+) T cells are usually thought of as the cells that are preferentially infected and killed by the virus. In a new study, Soghoian et al. now show that during the early stages of HIV infection, CD4(+) T cells suppress virus replication and delay disease onset. Thus, the robustness of the CD4(+) T cell response during early HIV infection could be used as a marker to determine the speed of disease progression. The new findings also have implications for the design of preventive and therapeutic AIDS vaccines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.